Abstract
The complement system was traditionally known as an effector arm of humoral immunity. Today we also recognize it as a main element of the innate immune system. In blood and other body fluids complement is a first line of defence against pathogens, because it becomes fully active within seconds. Active complement fragments attach to the invading pathogen to promote opsonization and lysis, triggering a local inflammatory response. This Review focuses on the evolving role of the complement system in the regulation of T-cell responses, from directing the initiation phase, through driving lineage commitment, to regulating the contraction phase.
Originalsprache | Englisch |
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Zeitschrift | Nature Reviews Immunology |
Jahrgang | 7 |
Ausgabenummer | 1 |
Seiten (von - bis) | 9-18 |
Seitenumfang | 10 |
ISSN | 1474-1733 |
DOIs | |
Publikationsstatus | Veröffentlicht - 01.2007 |
Strategische Forschungsbereiche und Zentren
- Forschungsschwerpunkt: Infektion und Entzündung - Zentrum für Infektions- und Entzündungsforschung Lübeck (ZIEL)