T cell receptor gene usage of BP180-specific T lymphocytes from patients with bullous pemphigoid and pemphigoid gestationis

Mary K. Hacker-Foegen; Detlef Zillikens; George J. Giudice; Mong Shang Lin

doi:10.1016/j.clim.2004.08.003

T cell receptor gene usage of BP180-specific T lymphocytes from patients with bullous pemphigoid and pemphigoid gestationis

Mary K. Hacker-Foegen, Detlef Zillikens, George J. Giudice, Mong Shang Lin

Klinik für Dermatologie, Allergologie und Venerologie

University of Wisconsin-Madison

13 Zitate (Scopus)

Abstract

BP180 is the autoantigen of different immunobullous diseases, including bullous pemphigoid (BP) and pemphigoid gestationis (PG). Previously, we demonstrated that the NC16A domain of this autoantigen harbors key epitopes of autoantibodies and T cells, indicating that it plays an essential role in the pathogenesis of diseases. Moreover, NC16A-specific T cell clones derived from these patients were shown to express a CD4+ memory T cell phenotype and secrete cytokines that may promote autoantibody production. In this study, we further characterize the properties of these T cells by analyzing their epitope specificity and T cell receptor (TCR) gene usage. We discovered that 83% of T cell clones obtained from BP patients preferentially express TCRBV13, while clones derived from a PG patient express the TCRBV3 gene. However, no preferential TCRBJ gene usage was identified. In conclusion, our results provide an advanced understanding of the characteristics of autoimmune T cells in immunobullous diseases.

Originalsprache	Englisch
Zeitschrift	Clinical Immunology
Jahrgang	113
Ausgabenummer	2
Seiten (von - bis)	179-186
Seitenumfang	8
ISSN	1521-6616
DOIs	https://doi.org/10.1016/j.clim.2004.08.003
Publikationsstatus	Veröffentlicht - 11.2004

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This work is supported in part by Public Health Service grants RO1-AR40410 (G.J.G.), RO1-AI48427 (M.S.L.), and Wilhelm Sander-Stiftung grant 98.073.2 (D.Z.). The authors also wish to give special thanks to Dr. Zelmira Lazarova for her critical reading of the manuscript and invaluable suggestions.

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10.1016/j.clim.2004.08.003

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@article{ba3d624f98354ca38092283f3f17b5ff,

title = "T cell receptor gene usage of BP180-specific T lymphocytes from patients with bullous pemphigoid and pemphigoid gestationis",

abstract = "BP180 is the autoantigen of different immunobullous diseases, including bullous pemphigoid (BP) and pemphigoid gestationis (PG). Previously, we demonstrated that the NC16A domain of this autoantigen harbors key epitopes of autoantibodies and T cells, indicating that it plays an essential role in the pathogenesis of diseases. Moreover, NC16A-specific T cell clones derived from these patients were shown to express a CD4+ memory T cell phenotype and secrete cytokines that may promote autoantibody production. In this study, we further characterize the properties of these T cells by analyzing their epitope specificity and T cell receptor (TCR) gene usage. We discovered that 83\% of T cell clones obtained from BP patients preferentially express TCRBV13, while clones derived from a PG patient express the TCRBV3 gene. However, no preferential TCRBJ gene usage was identified. In conclusion, our results provide an advanced understanding of the characteristics of autoimmune T cells in immunobullous diseases.",

author = "Hacker-Foegen, \{Mary K.\} and Detlef Zillikens and Giudice, \{George J.\} and Lin, \{Mong Shang\}",

note = "Funding Information: This work is supported in part by Public Health Service grants RO1-AR40410 (G.J.G.), RO1-AI48427 (M.S.L.), and Wilhelm Sander-Stiftung grant 98.073.2 (D.Z.). The authors also wish to give special thanks to Dr. Zelmira Lazarova for her critical reading of the manuscript and invaluable suggestions.",

year = "2004",

month = nov,

doi = "10.1016/j.clim.2004.08.003",

language = "English",

volume = "113",

pages = "179--186",

journal = "Clinical Immunology",

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T1 - T cell receptor gene usage of BP180-specific T lymphocytes from patients with bullous pemphigoid and pemphigoid gestationis

AU - Hacker-Foegen, Mary K.

AU - Zillikens, Detlef

AU - Giudice, George J.

AU - Lin, Mong Shang

N1 - Funding Information: This work is supported in part by Public Health Service grants RO1-AR40410 (G.J.G.), RO1-AI48427 (M.S.L.), and Wilhelm Sander-Stiftung grant 98.073.2 (D.Z.). The authors also wish to give special thanks to Dr. Zelmira Lazarova for her critical reading of the manuscript and invaluable suggestions.

PY - 2004/11

Y1 - 2004/11

N2 - BP180 is the autoantigen of different immunobullous diseases, including bullous pemphigoid (BP) and pemphigoid gestationis (PG). Previously, we demonstrated that the NC16A domain of this autoantigen harbors key epitopes of autoantibodies and T cells, indicating that it plays an essential role in the pathogenesis of diseases. Moreover, NC16A-specific T cell clones derived from these patients were shown to express a CD4+ memory T cell phenotype and secrete cytokines that may promote autoantibody production. In this study, we further characterize the properties of these T cells by analyzing their epitope specificity and T cell receptor (TCR) gene usage. We discovered that 83% of T cell clones obtained from BP patients preferentially express TCRBV13, while clones derived from a PG patient express the TCRBV3 gene. However, no preferential TCRBJ gene usage was identified. In conclusion, our results provide an advanced understanding of the characteristics of autoimmune T cells in immunobullous diseases.

AB - BP180 is the autoantigen of different immunobullous diseases, including bullous pemphigoid (BP) and pemphigoid gestationis (PG). Previously, we demonstrated that the NC16A domain of this autoantigen harbors key epitopes of autoantibodies and T cells, indicating that it plays an essential role in the pathogenesis of diseases. Moreover, NC16A-specific T cell clones derived from these patients were shown to express a CD4+ memory T cell phenotype and secrete cytokines that may promote autoantibody production. In this study, we further characterize the properties of these T cells by analyzing their epitope specificity and T cell receptor (TCR) gene usage. We discovered that 83% of T cell clones obtained from BP patients preferentially express TCRBV13, while clones derived from a PG patient express the TCRBV3 gene. However, no preferential TCRBJ gene usage was identified. In conclusion, our results provide an advanced understanding of the characteristics of autoimmune T cells in immunobullous diseases.

UR - https://www.scopus.com/pages/publications/4644330207

U2 - 10.1016/j.clim.2004.08.003

DO - 10.1016/j.clim.2004.08.003

M3 - Journal articles

C2 - 15451475

AN - SCOPUS:4644330207

SN - 1521-6616

VL - 113

SP - 179

EP - 186

JO - Clinical Immunology

JF - Clinical Immunology

IS - 2

ER -

T cell receptor gene usage of BP180-specific T lymphocytes from patients with bullous pemphigoid and pemphigoid gestationis

Abstract

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