Syringes with rubber-coated plungers and inactivation of surfactant

Egbert Herting*, Guido Stichtenoth, Bengt Robertson

*Korrespondierende/r Autor/-in für diese Arbeit
4 Zitate (Scopus)

Abstract

Injectable drugs are generally administered to newborns with 1 mL syringes. During in-vitro measurements of surface tension with a pulsating bubble surfactometer, we noticed that surfactant was inactivated after repeated aspiration into a 1 mL syringe with a rubber-coated plunger. Inactivation did not take place, however, when we used rubber-free two-part syringes with polyethylene pistons. Results of further studies showed that the silicone fluid used to lubricate the rubber surface of the syringe was inactivating the surfactant. Our findings suggest that contact with rubber surfaces should be avoided in the handling of surfactant material for biophysical assessment or clinical use.

OriginalspracheEnglisch
ZeitschriftLancet
Jahrgang361
Ausgabenummer9354
Seiten (von - bis)311-313
Seitenumfang3
ISSN0140-6736
DOIs
PublikationsstatusVeröffentlicht - 25.01.2003

Strategische Forschungsbereiche und Zentren

  • Forschungsschwerpunkt: Gehirn, Hormone, Verhalten - Center for Brain, Behavior and Metabolism (CBBM)

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