Synthesis and biological applications of 2,, 3l-dideoxynucleoside-5'-o-(<x-77//0)TRIPHOSPHATES

M. Auer; R. S. Goody; G. Sczakiel; S. WeiB

doi:10.1080/07328318908054228

Synthesis and biological applications of 2,, 3^l-dideoxynucleoside-5'-o-(<x-77//0)TRIPHOSPHATES

M. Auer, R. S. Goody, G. Sczakiel, S. WeiB

Abstract

Fast and efficient syntheses of 2-3, -dideoxynucleoside-5, -0-(a-f/t2o)tiiphosphates (a-S-ddNTP’s) starting from 2'-deoxynucleosides are described. They have been used in a modified DNA-sequencing method and were tested as potential inhibitors of HIV-1 reverse transcriptase. An X-ray structure of 3'-deoxythymidine is presented and compared to other known T-dideoxynucleoside structures.

Originalsprache	Englisch
Zeitschrift	Nucleosides and Nucleotides
Jahrgang	8
Ausgabenummer	5-6
Seiten (von - bis)	849-853
Seitenumfang	5
ISSN	0732-8311
DOIs	https://doi.org/10.1080/07328318908054228
Publikationsstatus	Veröffentlicht - 01.01.1989

UN SDGs

Dieser Output leistet einen Beitrag zu folgendem(n) Ziel(en) für nachhaltige Entwicklung

SDG 3 – Gesundheit und Wohlergehen

Dokumente

10.1080/07328318908054228

Weitere Links

Link to publication in Scopus

Zitieren

@article{c0f096fe199645fab0919956699ea6b4,

title = "Synthesis and biological applications of 2,, 3l-dideoxynucleoside-5'-o-(",

abstract = "Fast and efficient syntheses of 2-3, -dideoxynucleoside-5, -0-(a-f/t2o)tiiphosphates (a-S-ddNTP{\textquoteright}s) starting from 2'-deoxynucleosides are described. They have been used in a modified DNA-sequencing method and were tested as potential inhibitors of HIV-1 reverse transcriptase. An X-ray structure of 3'-deoxythymidine is presented and compared to other known T-dideoxynucleoside structures.",

author = "M. Auer and Goody, \{R. S.\} and G. Sczakiel and S. WeiB",

year = "1989",

month = jan,

day = "1",

doi = "10.1080/07328318908054228",

language = "English",

volume = "8",

pages = "849--853",

journal = "Nucleosides and Nucleotides",

issn = "0732-8311",

publisher = "Marcel Dekker Inc.",

number = "5-6",

}

TY - JOUR

T1 - Synthesis and biological applications of 2,, 3l-dideoxynucleoside-5'-o-(

AU - Auer, M.

AU - Goody, R. S.

AU - Sczakiel, G.

AU - WeiB, S.

PY - 1989/1/1

Y1 - 1989/1/1

N2 - Fast and efficient syntheses of 2-3, -dideoxynucleoside-5, -0-(a-f/t2o)tiiphosphates (a-S-ddNTP’s) starting from 2'-deoxynucleosides are described. They have been used in a modified DNA-sequencing method and were tested as potential inhibitors of HIV-1 reverse transcriptase. An X-ray structure of 3'-deoxythymidine is presented and compared to other known T-dideoxynucleoside structures.

AB - Fast and efficient syntheses of 2-3, -dideoxynucleoside-5, -0-(a-f/t2o)tiiphosphates (a-S-ddNTP’s) starting from 2'-deoxynucleosides are described. They have been used in a modified DNA-sequencing method and were tested as potential inhibitors of HIV-1 reverse transcriptase. An X-ray structure of 3'-deoxythymidine is presented and compared to other known T-dideoxynucleoside structures.

UR - https://www.scopus.com/pages/publications/0024312673

U2 - 10.1080/07328318908054228

DO - 10.1080/07328318908054228

M3 - Journal articles

AN - SCOPUS:0024312673

SN - 0732-8311

VL - 8

SP - 849

EP - 853

JO - Nucleosides and Nucleotides

JF - Nucleosides and Nucleotides

IS - 5-6

ER -