Synthesis and biological applications of 2,, 3l-dideoxynucleoside-5'-o-(<x-77//0)TRIPHOSPHATES

M. Auer, R. S. Goody, G. Sczakiel, S. WeiB

3 Zitate (Scopus)

Abstract

Fast and efficient syntheses of 2-3, -dideoxynucleoside-5, -0-(a-f/t2o)tiiphosphates (a-S-ddNTP’s) starting from 2'-deoxynucleosides are described. They have been used in a modified DNA-sequencing method and were tested as potential inhibitors of HIV-1 reverse transcriptase. An X-ray structure of 3'-deoxythymidine is presented and compared to other known T-dideoxynucleoside structures.

OriginalspracheEnglisch
ZeitschriftNucleosides and Nucleotides
Jahrgang8
Ausgabenummer5-6
Seiten (von - bis)849-853
Seitenumfang5
ISSN0732-8311
DOIs
PublikationsstatusVeröffentlicht - 01.01.1989

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