Abstract
Fast and efficient syntheses of 2-3, -dideoxynucleoside-5, -0-(a-f/t2o)tiiphosphates (a-S-ddNTP’s) starting from 2'-deoxynucleosides are described. They have been used in a modified DNA-sequencing method and were tested as potential inhibitors of HIV-1 reverse transcriptase. An X-ray structure of 3'-deoxythymidine is presented and compared to other known T-dideoxynucleoside structures.
Originalsprache | Englisch |
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Zeitschrift | Nucleosides and Nucleotides |
Jahrgang | 8 |
Ausgabenummer | 5-6 |
Seiten (von - bis) | 849-853 |
Seitenumfang | 5 |
ISSN | 0732-8311 |
DOIs | |
Publikationsstatus | Veröffentlicht - 01.01.1989 |