Structural insights into hepatitis C virus neutralization

Luisa J. Ströh; Thomas Krey

doi:10.1016/j.coviro.2023.101316

Structural insights into hepatitis C virus neutralization

Luisa J. Ströh, Thomas Krey

Institut für Biochemie

Medizinische Hochschule Hannover

5 Zitate (Scopus)

Abstract

Inspite of the available antiviral therapy, hepatitis C virus (HCV) remains a global health burden and a prophylactic vaccine would help to eliminate the risk to develop chronic liver diseases. Structural insights into the function of the glycoproteins E1 and E2 in virus entry and the interplay with the host's humoral immune response are key for informed vaccine development. We review recently reported structural insights into receptor binding of HCV glycoproteins and the assembly of an intact membrane-bound E1–E2 heterodimer. These data are used together with available functional data to draw a simplified model of virus entry, which highlights gaps in our current knowledge that warrant further research to fully understand this process at the atomic level.

Originalsprache	Englisch
Aufsatznummer	101316
Zeitschrift	Current Opinion in Virology
Jahrgang	60
ISSN	1879-6257
DOIs	https://doi.org/10.1016/j.coviro.2023.101316
Publikationsstatus	Veröffentlicht - 06.2023

Fördermittel

This work was funded by the Deutsche Forschungsgemeinschaft (DFG, German Research Foundation, Germany) under Germany’s Excellence Strategy — EXC 2155 — Projektnummer 390874280 (TK) and by the Deutsche Forschungsgemeinschaft (DFG, German Research Foundation, Germany) within project B10 of the Collaborative Research Centre SFB900 — Projektnummer 158989968 (TK and LS).

UN SDGs

Dieser Output leistet einen Beitrag zu folgendem(n) Ziel(en) für nachhaltige Entwicklung

SDG 3 – Gesundheit und Wohlergehen

Strategische Forschungsbereiche und Zentren

Forschungsschwerpunkt: Infektion und Entzündung - Zentrum für Infektions- und Entzündungsforschung Lübeck (ZIEL)
Zentren: Zentrum für Medizinische Struktur- und Zellbiologie (ZMSZ)

DFG-Fachsystematik

2.21-04 Virologie
2.11-04 Strukturbiologie

Dokumente

10.1016/j.coviro.2023.101316

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title = "Structural insights into hepatitis C virus neutralization",

abstract = "Inspite of the available antiviral therapy, hepatitis C virus (HCV) remains a global health burden and a prophylactic vaccine would help to eliminate the risk to develop chronic liver diseases. Structural insights into the function of the glycoproteins E1 and E2 in virus entry and the interplay with the host's humoral immune response are key for informed vaccine development. We review recently reported structural insights into receptor binding of HCV glycoproteins and the assembly of an intact membrane-bound E1–E2 heterodimer. These data are used together with available functional data to draw a simplified model of virus entry, which highlights gaps in our current knowledge that warrant further research to fully understand this process at the atomic level.",

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N2 - Inspite of the available antiviral therapy, hepatitis C virus (HCV) remains a global health burden and a prophylactic vaccine would help to eliminate the risk to develop chronic liver diseases. Structural insights into the function of the glycoproteins E1 and E2 in virus entry and the interplay with the host's humoral immune response are key for informed vaccine development. We review recently reported structural insights into receptor binding of HCV glycoproteins and the assembly of an intact membrane-bound E1–E2 heterodimer. These data are used together with available functional data to draw a simplified model of virus entry, which highlights gaps in our current knowledge that warrant further research to fully understand this process at the atomic level.

AB - Inspite of the available antiviral therapy, hepatitis C virus (HCV) remains a global health burden and a prophylactic vaccine would help to eliminate the risk to develop chronic liver diseases. Structural insights into the function of the glycoproteins E1 and E2 in virus entry and the interplay with the host's humoral immune response are key for informed vaccine development. We review recently reported structural insights into receptor binding of HCV glycoproteins and the assembly of an intact membrane-bound E1–E2 heterodimer. These data are used together with available functional data to draw a simplified model of virus entry, which highlights gaps in our current knowledge that warrant further research to fully understand this process at the atomic level.

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DO - 10.1016/j.coviro.2023.101316

M3 - Scientific review articles

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VL - 60

JO - Current Opinion in Virology

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M1 - 101316

ER -

Structural insights into hepatitis C virus neutralization

Abstract

Fördermittel

UN SDGs

Strategische Forschungsbereiche und Zentren

DFG-Fachsystematik

Dokumente

Weitere Links

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