Structural brain abnormalities in cervical dystonia

Tino Prell*, Thomas Peschel, Bernadette Köhler, Martin H. Bokemeyer, Reinhard Dengler, Albrecht Günther, Julian Grosskreutz

*Korrespondierende/r Autor/-in für diese Arbeit
40 Zitate (Scopus)

Abstract

Background: Idiopathic cervical dystonia is characterized by involuntary spasms, tremors or jerks. It is not restricted to a disturbance in the basal ganglia system because non-conventional voxel-based MRI morphometry (VBM) and diffusion tensor imaging (DTI) have detected numerous regional changes in the brains of patients. In this study scans of 24 patients with cervical dystonia and 24 age-and sex-matched controls were analysed using VBM, DTI and magnetization transfer imaging (MTI) using a voxel-based approach and a region-of-interest analysis. Results were correlated with UDRS, TWSTRS and disease duration. Results: We found structural alterations in the basal ganglia; thalamus; motor cortex; premotor cortex; frontal, temporal and parietal cortices; visual system; cerebellum and brainstem of the patients with dystonia. Conclusions: Cervical dystonia is a multisystem disease involving several networks such as the motor, sensory and visual systems.

OriginalspracheEnglisch
Aufsatznummer123
ZeitschriftBMC Neuroscience
Jahrgang14
ISSN0306-4522
DOIs
PublikationsstatusVeröffentlicht - 16.10.2013
Extern publiziertJa

Strategische Forschungsbereiche und Zentren

  • Zentren: Neuromuskuläres Zentrum Schleswig-Holstein

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