Stromal niches, plasma cell differentiation and survival

Katrin Moser*, Koji Tokoyoda, Andreas Radbruch, Ian MacLennan, Rudolf A. Manz

*Korrespondierende/r Autor/-in für diese Arbeit
114 Zitate (Scopus)

Abstract

Contacts made with other cells and stroma have a major impact on proliferation, differentiation, survival, migration and immunoglobulin class switching of plasma cell precursors as well as on the lifespan of the antibody-secreting cells. Induction of tissue-specific chemokine receptors and adhesion molecules directs migratory plasma cell precursors to tissues close to those in which the original immune stimulation occurred. This mechanism focuses the production of specific antibodies within a particular type of tissue, thus providing a means for the most efficient protection against tissue-specific pathogens. Relocation does not apply to long-lived plasma cells responsible for sustained titers of high-affinity systemic antibody. These are formed in germinal centers and migrate to specific niches in the bone marrow that support their further differentiation and long-term survival.

OriginalspracheEnglisch
ZeitschriftCurrent Opinion in Immunology
Jahrgang18
Ausgabenummer3
Seiten (von - bis)265-270
Seitenumfang6
ISSN0952-7915
DOIs
PublikationsstatusVeröffentlicht - 06.2006

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