Abstract
BACKGROUND/AIM: Most patients with resected brain metastases receive post-operative radiotherapy. This study investigated outcomes of fractionated stereotactic radiotherapy (FSRT) alone or whole-brain irradiation plus simultaneous integrated boost (WBI+SIB) in the post-operative setting. PATIENTS AND METHODS: Forty-four patients receiving FSRT alone (n=32) or WBI+SIB (n=12) after resection of 1-3 brain metastases from 2014-2022 were analyzed. Twelve factors were evaluated for local control (LC), distant brain control (DBC), and overall survival (OS). RESULTS: On univariate and multivariate analyses, single brain metastasis was associated with improved LC and DBC. Longer interval between tumor diagnosis and radiotherapy, single brain metastasis, and Karnofsky performance score >80 were associated with improved OS. WBI+SIB showed a trend towards better DBC. CONCLUSION: Several independent predictors of outcomes after FSRT or WBI+SIB following resection of brain metastases were identified. Given similar survival in the post-operative setting between FSRT and WBI+SIB, potential toxicity remains a significant factor in treatment recommendations.
Originalsprache | Englisch |
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Zeitschrift | Anticancer Research |
Jahrgang | 43 |
Ausgabenummer | 6 |
Seiten (von - bis) | 2763-2770 |
Seitenumfang | 8 |
ISSN | 0250-7005 |
DOIs | |
Publikationsstatus | Veröffentlicht - 01.06.2023 |
Strategische Forschungsbereiche und Zentren
- Profilbereich: Lübeck Integrated Oncology Network (LION)
- Zentren: Universitäres Cancer Center Schleswig-Holstein (UCCSH)
DFG-Fachsystematik
- 2.22-30 Radiologie
- 2.22-14 Hämatologie, Onkologie