Stellenwert der histologischen untersuchung in der diagnostik bullöser autoimmundermatosen

Christian Rose*, Eva Bettina Bröcker, Detlef Zillikens

*Korrespondierende/r Autor/-in für diese Arbeit
8 Zitate (Scopus)

Abstract

The histopathological picture of many autoimmune bullous dermatoses is considered to be relatively characteristic. However, different entities may show similar histological findings. In addition, the picture depends on both the stage of the disease and prior treatment. Autoimmune bullous dermatoses are characterized by the production of autoantibodies to structural proteins of the skin. In most instances, the autoantigens have been identified and are available as recombinant proteins. Utilizing these recombinant forms, specific and sensitive assays have been developed for the detection of circulating autoantibodies in the serum. The detection of autoantibodies in skin or mucous membranes and/or serum is required for the diagnosis of autoimmune bullous dermatoses. The task of the dermatopathologist in the diagnostic process of autoimmune bullous dermatoses is to describe precisely the histopathological findings, to mention differential diagnoses and to recommend how these can be confirmed or excluded by immunopathological and immunoserological studies.

Titel in ÜbersetzungRelevance of histological examination in the diagnosis of autoimmune bullous dermatoses
OriginalspracheDeutsch
ZeitschriftJDDG - Journal of the German Society of Dermatology
Jahrgang2
Ausgabenummer2
Seiten (von - bis)96-104
Seitenumfang9
ISSN1610-0379
DOIs
PublikationsstatusVeröffentlicht - 02.2004

Fingerprint

Untersuchen Sie die Forschungsthemen von „Stellenwert der histologischen untersuchung in der diagnostik bullöser autoimmundermatosen“. Zusammen bilden sie einen einzigartigen Fingerprint.

Zitieren