Spectroscopic studies on iron complexes of different anthracyclines in aprotic solvent systems

H. Drechsel; M. Fiallo; A. Garnier-Suillerot; B. F. Matzanke; V. Schünemann

doi:10.1021/ic0002723

Spectroscopic studies on iron complexes of different anthracyclines in aprotic solvent systems

H. Drechsel^*, M. Fiallo, A. Garnier-Suillerot, B. F. Matzanke, V. Schünemann

^*Korrespondierende/r Autor/-in für diese Arbeit

Institut für Physik

15 Zitate (Scopus)

Abstract

The iron complexes of daunorubicin, idarubicin, pirarubicin, and doxorubicin were prepared in anhydrous DMF and studied by absorption, circular dichroism, Mössbauer, and EPR spectroscopy. Metal complexation was studied in titration series at different metal/ligand ratios. Optical spectroscopy indicates the existance of two different complex species, which were further characterized by EPR and Mössbauer experiments. Structural models for both complex species, differing in complexation mode and degree of oligomerization, are proposed.

Originalsprache	Englisch
Zeitschrift	Inorganic Chemistry
Jahrgang	40
Ausgabenummer	21
Seiten (von - bis)	5324-5333
Seitenumfang	10
ISSN	0020-1669
DOIs	https://doi.org/10.1021/ic0002723
Publikationsstatus	Veröffentlicht - 08.10.2001

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10.1021/ic0002723

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title = "Spectroscopic studies on iron complexes of different anthracyclines in aprotic solvent systems",

abstract = "The iron complexes of daunorubicin, idarubicin, pirarubicin, and doxorubicin were prepared in anhydrous DMF and studied by absorption, circular dichroism, M{\"o}ssbauer, and EPR spectroscopy. Metal complexation was studied in titration series at different metal/ligand ratios. Optical spectroscopy indicates the existance of two different complex species, which were further characterized by EPR and M{\"o}ssbauer experiments. Structural models for both complex species, differing in complexation mode and degree of oligomerization, are proposed.",

author = "H. Drechsel and M. Fiallo and A. Garnier-Suillerot and Matzanke, {B. F.} and V. Sch{\"u}nemann",

year = "2001",

month = oct,

day = "8",

doi = "10.1021/ic0002723",

language = "English",

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journal = "Inorganic Chemistry",

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T1 - Spectroscopic studies on iron complexes of different anthracyclines in aprotic solvent systems

AU - Drechsel, H.

AU - Fiallo, M.

AU - Garnier-Suillerot, A.

AU - Matzanke, B. F.

AU - Schünemann, V.

PY - 2001/10/8

Y1 - 2001/10/8

N2 - The iron complexes of daunorubicin, idarubicin, pirarubicin, and doxorubicin were prepared in anhydrous DMF and studied by absorption, circular dichroism, Mössbauer, and EPR spectroscopy. Metal complexation was studied in titration series at different metal/ligand ratios. Optical spectroscopy indicates the existance of two different complex species, which were further characterized by EPR and Mössbauer experiments. Structural models for both complex species, differing in complexation mode and degree of oligomerization, are proposed.

AB - The iron complexes of daunorubicin, idarubicin, pirarubicin, and doxorubicin were prepared in anhydrous DMF and studied by absorption, circular dichroism, Mössbauer, and EPR spectroscopy. Metal complexation was studied in titration series at different metal/ligand ratios. Optical spectroscopy indicates the existance of two different complex species, which were further characterized by EPR and Mössbauer experiments. Structural models for both complex species, differing in complexation mode and degree of oligomerization, are proposed.

UR - http://www.scopus.com/inward/record.url?scp=0035828871&partnerID=8YFLogxK

U2 - 10.1021/ic0002723

DO - 10.1021/ic0002723

M3 - Journal articles

C2 - 11578175

AN - SCOPUS:0035828871

SN - 0020-1669

VL - 40

SP - 5324

EP - 5333

JO - Inorganic Chemistry

JF - Inorganic Chemistry

IS - 21

ER -

Spectroscopic studies on iron complexes of different anthracyclines in aprotic solvent systems

Abstract

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