Specific recognition of proteins by array-bound hexanucleotides

Alessandra Mescalchin; Winfried Wünsche; Georg Sczakiel

doi:10.1002/anie.201003462

Specific recognition of proteins by array-bound hexanucleotides

Alessandra Mescalchin^*, Winfried Wünsche, Georg Sczakiel

^*Korrespondierende/r Autor/-in für diese Arbeit

Christian-Albrechts Universität zu Kiel

4 Zitate (Scopus)

Abstract

Maximum information density: The complete hexanucleotide sequence space can be immobilized on a chip. The binding of a number of proteins was profiled with this array of 4096 sequences, including fluorescently labeled forms of the HIV-2 and HIV-1 reverse transciptases (the consensus motif is shown in the picture). This new technique should aid in the search for pharmaceutical lead compunds.

Originalsprache	Englisch
Zeitschrift	Angewandte Chemie - International Edition
Jahrgang	50
Ausgabenummer	5
Seiten (von - bis)	1052-1054
Seitenumfang	3
ISSN	1433-7851
DOIs	https://doi.org/10.1002/anie.201003462
Publikationsstatus	Veröffentlicht - 01.02.2011

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10.1002/anie.201003462

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AB - Maximum information density: The complete hexanucleotide sequence space can be immobilized on a chip. The binding of a number of proteins was profiled with this array of 4096 sequences, including fluorescently labeled forms of the HIV-2 and HIV-1 reverse transciptases (the consensus motif is shown in the picture). This new technique should aid in the search for pharmaceutical lead compunds.

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Specific recognition of proteins by array-bound hexanucleotides

Abstract

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