TY - JOUR
T1 - Smoking influence in Takotsubo syndrome
T2 - insights from an international cohort
AU - Núñez-Gil, Iván J.
AU - Santoro, Francesco
AU - Vazirani, Ravi
AU - Novo, Giuseppina
AU - Blanco-Ponce, Emilia
AU - Arcari, Luca
AU - Uribarri, Aitor
AU - Cacciotti, Luca
AU - Guerra, Federico
AU - Salamanca, Jorge
AU - Musumeci, Beatrice
AU - Vedia, Oscar
AU - Mariano, Enrica
AU - Fernández-Cordón, Clara
AU - Caldarola, Pasquale
AU - Montisci, Roberta
AU - Brunetti, Natale Daniele
AU - El-Battrawy, Ibrahim
AU - Abumayyaleh, Mohammad
AU - Akin, Ibrahim
AU - Eitel, Ingo
AU - Stiermaier, Thomas
N1 - Publisher Copyright:
2023 Núñez-Gil, Santoro, Vazirani, Novo, Blanco-Ponce, Arcari, Uribarri, Cacciotti, Guerra, Salamanca, Musumeci, Vedia, Mariano, Fernández-Cordón, Caldarola, Montisci, Brunetti, El-Battrawy, Abumayyaleh, Akin, Eitel and Stiermaier.
PY - 2023
Y1 - 2023
N2 - Aims: To assess the influence of tobacco on acute and long-term outcomes in Takotsubo syndrome (TTS). Methods: Patients with TTS from the international multicenter German Italian Spanish Takotsubo registry (GEIST) were analyzed. Comparisons between groups were performed within the overall cohort, and an adjusted analysis with 1:1 propensity score matching was conducted. Results: Out of 3,152 patients with TTS, 534 (17%) were current smokers. Smoker TTS patients were younger (63 ± 11 vs. 72 ± 11 years, p < 0.001), less frequently women (78% vs. 90%, p < 0.001), and had a lower prevalence of hypertension (59% vs. 69%, p < 0.01) and diabetes mellitus (16% vs. 20%, p = 0.04), but had a higher prevalence of pulmonary (21% vs. 15%, p < 0.01) and/or psychiatric diseases (17% vs. 12%, p < 0.01). On multivariable analysis, age less than 65 years [OR 3.85, 95% CI (2.86–5)], male gender [OR 2.52, 95% CI (1.75–3.64)], history of pulmonary disease [OR 2.56, 95% CI (1.81–3.61)], coronary artery disease [OR 2.35, 95% CI (1.60–3.46)], and non-apical ballooning form [OR 1.47, 95% CI (1.02–2.13)] were associated with smoking status. Propensity score matching (PSM) 1:1 yielded 329 patients from each group. Smokers had a similar rate of in-hospital complications but longer in-hospital stays (10 vs. 9 days, p = 0.01). During long-term follow-up, there were no differences in mortality rates between smokers and non-smokers (5.6% vs. 6.9% yearly in the overall, p = 0.02, and 6.6%, vs. 7.2% yearly in the matched cohort, p = 0.97). Conclusions: Our findings suggest that smoking may influence the clinical presentation and course of TTS with longer in-hospital stays, but does not independently impact mortality.
AB - Aims: To assess the influence of tobacco on acute and long-term outcomes in Takotsubo syndrome (TTS). Methods: Patients with TTS from the international multicenter German Italian Spanish Takotsubo registry (GEIST) were analyzed. Comparisons between groups were performed within the overall cohort, and an adjusted analysis with 1:1 propensity score matching was conducted. Results: Out of 3,152 patients with TTS, 534 (17%) were current smokers. Smoker TTS patients were younger (63 ± 11 vs. 72 ± 11 years, p < 0.001), less frequently women (78% vs. 90%, p < 0.001), and had a lower prevalence of hypertension (59% vs. 69%, p < 0.01) and diabetes mellitus (16% vs. 20%, p = 0.04), but had a higher prevalence of pulmonary (21% vs. 15%, p < 0.01) and/or psychiatric diseases (17% vs. 12%, p < 0.01). On multivariable analysis, age less than 65 years [OR 3.85, 95% CI (2.86–5)], male gender [OR 2.52, 95% CI (1.75–3.64)], history of pulmonary disease [OR 2.56, 95% CI (1.81–3.61)], coronary artery disease [OR 2.35, 95% CI (1.60–3.46)], and non-apical ballooning form [OR 1.47, 95% CI (1.02–2.13)] were associated with smoking status. Propensity score matching (PSM) 1:1 yielded 329 patients from each group. Smokers had a similar rate of in-hospital complications but longer in-hospital stays (10 vs. 9 days, p = 0.01). During long-term follow-up, there were no differences in mortality rates between smokers and non-smokers (5.6% vs. 6.9% yearly in the overall, p = 0.02, and 6.6%, vs. 7.2% yearly in the matched cohort, p = 0.97). Conclusions: Our findings suggest that smoking may influence the clinical presentation and course of TTS with longer in-hospital stays, but does not independently impact mortality.
UR - http://www.scopus.com/inward/record.url?scp=85178935303&partnerID=8YFLogxK
U2 - 10.3389/fcvm.2023.1282018
DO - 10.3389/fcvm.2023.1282018
M3 - Journal articles
AN - SCOPUS:85178935303
SN - 2297-055X
VL - 10
JO - Frontiers in Cardiovascular Medicine
JF - Frontiers in Cardiovascular Medicine
M1 - 1282018
ER -
