Small intestine vs. colon ecology and physiology: Why it matters in probiotic administration

Benjamin Anderschou Holbech Jensen; Marc Heyndrickx; Daisy Jonkers; Alan Mackie; Sam Millet; Malwina Naghibi; Simone Isling Pærregaard; Bruno Pot; Delphine Saulnier; Christian Sina; Luc Gerardus Willibrordus Sterkman; Pieter Van den Abbeele; Naomi Vita Venlet; Erwin G. Zoetendal; Arthur Constantijn Ouwehand

doi:10.1016/j.xcrm.2023.101190

Small intestine vs. colon ecology and physiology: Why it matters in probiotic administration

Benjamin Anderschou Holbech Jensen^*, Marc Heyndrickx, Daisy Jonkers, Alan Mackie, Sam Millet, Malwina Naghibi, Simone Isling Pærregaard, Bruno Pot, Delphine Saulnier, Christian Sina, Luc Gerardus Willibrordus Sterkman, Pieter Van den Abbeele, Naomi Vita Venlet^*, Erwin G. Zoetendal, Arthur Constantijn Ouwehand

^*Korrespondierende/r Autor/-in für diese Arbeit

Institut für Ernährungsmedizin

96 Zitate (Scopus)

Abstract

Research on gut microbiota has generally focused on fecal samples, representing luminal content of the large intestine. However, nutrient uptake is restricted to the small intestine. Abundant immune cell populations at this anatomical site combined with diminished mucus secretion and looser junctions (partly to allow for more efficient fluid and nutrient absorption) also results in intimate host-microbe interactions despite more rapid transit. It is thus crucial to dissect key differences in both ecology and physiology between small and large intestine to better leverage the immense potential of human gut microbiota imprinting, including probiotic engraftment at biological sensible niches. Here, we provide a detailed review unfolding how the physiological and anatomical differences between the small and large intestine affect gut microbiota composition, function, and plasticity. This information is key to understanding how gut microbiota manipulation, including probiotic administration, may strain-dependently transform host-microbe interactions at defined locations.

Originalsprache	Englisch
Aufsatznummer	101190
Zeitschrift	Cell Reports Medicine
Jahrgang	4
Ausgabenummer	9
DOIs	https://doi.org/10.1016/j.xcrm.2023.101190
Publikationsstatus	Veröffentlicht - 19.09.2023

Fördermittel

This work was conducted by an expert group (EG) of ILSI Europe. Composition of the EG is listed on the ILSI Europe website at https://ilsi.eu/scientific-activities/nutrition/probiotics/. ILSI Europe facilitated scientific meetings and coordinated the overall project management and administrative tasks relating to the completion of this work. This manuscript was copy edited by Cath Mersh. Traveling and accommodation expenses were covered by ILSI Europe. All authors contributed to design and writing of the first manuscript draft. B.A.H.J. and A.C.O. led the process of editing and contextualizing the body text while integrating the contributions of each individual author. B.A.H.J. was responsible for the final editing of the manuscript. First and last authors are positioned according to standard guidelines. Remaining authors are ordered alphabetically, emphasizing the joint effort. A.C.O. M.N. B.P. D.S. L.G.W.S. and P.V.D.A. work full time for IFF, ADM, Yakult, Novozymes, Caelus Health, and Cryptobiotix respectively. These companies were not involved in carrying out this research.

UN SDGs

Dieser Output leistet einen Beitrag zu folgendem(n) Ziel(en) für nachhaltige Entwicklung

SDG 3 – Gesundheit und Wohlergehen

Strategische Forschungsbereiche und Zentren

Forschungsschwerpunkt: Gehirn, Hormone, Verhalten - Center for Brain, Behavior and Metabolism (CBBM)
Forschungsschwerpunkt: Infektion und Entzündung - Zentrum für Infektions- und Entzündungsforschung Lübeck (ZIEL)

DFG-Fachsystematik

2.22-05 Ernährungswissenschaften
2.21-01 Stoffwechselphysiologie, Biochemie und Genetik der Mikroorganismen

Dokumente

10.1016/j.xcrm.2023.101190

Weitere Links

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Jensen, B. A. H., Heyndrickx, M., Jonkers, D., Mackie, A., Millet, S., Naghibi, M., Pærregaard, S. I., Pot, B., Saulnier, D., Sina, C., Sterkman, L. G. W., Van den Abbeele, P., Venlet, N. V., Zoetendal, E. G., & Ouwehand, A. C. (2023). Small intestine vs. colon ecology and physiology: Why it matters in probiotic administration. Cell Reports Medicine, 4(9), Artikel 101190. https://doi.org/10.1016/j.xcrm.2023.101190

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title = "Small intestine vs. colon ecology and physiology: Why it matters in probiotic administration",

abstract = "Research on gut microbiota has generally focused on fecal samples, representing luminal content of the large intestine. However, nutrient uptake is restricted to the small intestine. Abundant immune cell populations at this anatomical site combined with diminished mucus secretion and looser junctions (partly to allow for more efficient fluid and nutrient absorption) also results in intimate host-microbe interactions despite more rapid transit. It is thus crucial to dissect key differences in both ecology and physiology between small and large intestine to better leverage the immense potential of human gut microbiota imprinting, including probiotic engraftment at biological sensible niches. Here, we provide a detailed review unfolding how the physiological and anatomical differences between the small and large intestine affect gut microbiota composition, function, and plasticity. This information is key to understanding how gut microbiota manipulation, including probiotic administration, may strain-dependently transform host-microbe interactions at defined locations.",

author = "Jensen, \{Benjamin Anderschou Holbech\} and Marc Heyndrickx and Daisy Jonkers and Alan Mackie and Sam Millet and Malwina Naghibi and P{\ae}rregaard, \{Simone Isling\} and Bruno Pot and Delphine Saulnier and Christian Sina and Sterkman, \{Luc Gerardus Willibrordus\} and \{Van den Abbeele\}, Pieter and Venlet, \{Naomi Vita\} and Zoetendal, \{Erwin G.\} and Ouwehand, \{Arthur Constantijn\}",

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Jensen, BAH, Heyndrickx, M, Jonkers, D, Mackie, A, Millet, S, Naghibi, M, Pærregaard, SI, Pot, B, Saulnier, D, Sina, C, Sterkman, LGW, Van den Abbeele, P, Venlet, NV, Zoetendal, EG & Ouwehand, AC 2023, 'Small intestine vs. colon ecology and physiology: Why it matters in probiotic administration', Cell Reports Medicine, Jg. 4, Nr. 9, 101190. https://doi.org/10.1016/j.xcrm.2023.101190

TY - JOUR

T1 - Small intestine vs. colon ecology and physiology

T2 - Why it matters in probiotic administration

AU - Jensen, Benjamin Anderschou Holbech

AU - Heyndrickx, Marc

AU - Jonkers, Daisy

AU - Mackie, Alan

AU - Millet, Sam

AU - Naghibi, Malwina

AU - Pærregaard, Simone Isling

AU - Pot, Bruno

AU - Saulnier, Delphine

AU - Sina, Christian

AU - Sterkman, Luc Gerardus Willibrordus

AU - Van den Abbeele, Pieter

AU - Venlet, Naomi Vita

AU - Zoetendal, Erwin G.

AU - Ouwehand, Arthur Constantijn

PY - 2023/9/19

Y1 - 2023/9/19

N2 - Research on gut microbiota has generally focused on fecal samples, representing luminal content of the large intestine. However, nutrient uptake is restricted to the small intestine. Abundant immune cell populations at this anatomical site combined with diminished mucus secretion and looser junctions (partly to allow for more efficient fluid and nutrient absorption) also results in intimate host-microbe interactions despite more rapid transit. It is thus crucial to dissect key differences in both ecology and physiology between small and large intestine to better leverage the immense potential of human gut microbiota imprinting, including probiotic engraftment at biological sensible niches. Here, we provide a detailed review unfolding how the physiological and anatomical differences between the small and large intestine affect gut microbiota composition, function, and plasticity. This information is key to understanding how gut microbiota manipulation, including probiotic administration, may strain-dependently transform host-microbe interactions at defined locations.

AB - Research on gut microbiota has generally focused on fecal samples, representing luminal content of the large intestine. However, nutrient uptake is restricted to the small intestine. Abundant immune cell populations at this anatomical site combined with diminished mucus secretion and looser junctions (partly to allow for more efficient fluid and nutrient absorption) also results in intimate host-microbe interactions despite more rapid transit. It is thus crucial to dissect key differences in both ecology and physiology between small and large intestine to better leverage the immense potential of human gut microbiota imprinting, including probiotic engraftment at biological sensible niches. Here, we provide a detailed review unfolding how the physiological and anatomical differences between the small and large intestine affect gut microbiota composition, function, and plasticity. This information is key to understanding how gut microbiota manipulation, including probiotic administration, may strain-dependently transform host-microbe interactions at defined locations.

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SN - 2666-3791

VL - 4

JO - Cell Reports Medicine

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ER -

Small intestine vs. colon ecology and physiology: Why it matters in probiotic administration

Abstract

Fördermittel

UN SDGs

Strategische Forschungsbereiche und Zentren

DFG-Fachsystematik

Dokumente

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