Sleep and circadian rhythms in Parkinson’s disease and preclinical models

Jeremy Hunt, Elizabeth J. Coulson, Rajendram Rajnarayanan, Henrik Oster, Aleksandar Videnovic, Oliver Rawashdeh*

*Korrespondierende/r Autor/-in für diese Arbeit
23 Zitate (Scopus)

Abstract

The use of animals as models of human physiology is, and has been for many years, an indispensable tool for understanding the mechanisms of human disease. In Parkinson’s disease, various mouse models form the cornerstone of these investigations. Early models were developed to reflect the traditional histological features and motor symptoms of Parkinson’s disease. However, it is important that models accurately encompass important facets of the disease to allow for comprehensive mechanistic understanding and translational significance. Circadian rhythm and sleep issues are tightly correlated to Parkinson’s disease, and often arise prior to the presentation of typical motor deficits. It is essential that models used to understand Parkinson’s disease reflect these dysfunctions in circadian rhythms and sleep, both to facilitate investigations into mechanistic interplay between sleep and disease, and to assist in the development of circadian rhythm-facing therapeutic treatments. This review describes the extent to which various genetically- and neurotoxically-induced murine models of Parkinson’s reflect the sleep and circadian abnormalities of Parkinson’s disease observed in the clinic.

OriginalspracheEnglisch
Aufsatznummer2
ZeitschriftMolecular Neurodegeneration
Jahrgang17
Ausgabenummer1
DOIs
PublikationsstatusVeröffentlicht - 12.2022

Strategische Forschungsbereiche und Zentren

  • Forschungsschwerpunkt: Gehirn, Hormone, Verhalten - Center for Brain, Behavior and Metabolism (CBBM)

DFG-Fachsystematik

  • 205-17 Endokrinologie, Diabetologie, Metabolismus
  • 206-08 Kognitive und Systemische Humanneurowissenschaften
  • 206-07 Klinische Neurologie; Neurochirurgie und Neuroradiologie

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