Short-term outcome of very-low-birthweight infants with arterial hypotension in the first 24 h of life

Kirstin Faust, Christoph Härtel, Michael Preuß, Heike Rabe, Claudia Roll, Michael Emeis, Christian Wieg, Miklos Szabo, Egbert Herting, Wolfgang Göpel*

*Korrespondierende/r Autor/-in für diese Arbeit
57 Zitate (Scopus)

Abstract

Objective: To evaluate lowest mean arterial blood pressure during the first 24 h of life (minMAP24) in verylowbirthweight (VLBW) infants and to identify associations between hypotension and short-term outcome. Design: Retrospective cohort analysis of the minMAP24 of 4907 VLBW infants with a gestational age <32 weeks in correlation with clinical data. Hypotension was defined as minMAP24 being lower than the median value of all patients of the same gestational age. Results: MinMAP24 values correlated with gestational age. Median minMAP24 values of VLBW infants ≤29 weeks' gestation were 1.2 mm Hg lower than gestational age in completed weeks. Hypotensive infants had a higher rate of intraventricular haemorrhage (IVH, 20.3% vs 15.9%, p<0.001), bronchopulmonary dysplasia (BPD, 19.2% vs 15.1%, p<0.001) and death (5.2% vs 3.0%, p<0.001). Multivariate logistic regression analyses, including potential confounders, confirmed these data. MinMAP24 was an independent risk factor for IVH (OR 0.97/mm Hg, 95% CI 0.96 to 0.99, p=0.003), BPD (OR 0.96/mm Hg, 95% CI 0.94 to 0.98, p<0.001) and mortality (OR 0.94/mm Hg, 95% CI 0.90 to 0.98, p=0.003). Conclusions: Hypotension during the first 24 h of life is associated with adverse outcomes in VLBW infants. This underlines the need for randomised controlled trials on the use of vasoactive drugs in this vulnerable patient cohort.

OriginalspracheEnglisch
ZeitschriftArchives of Disease in Childhood: Fetal and Neonatal Edition
Jahrgang100
Ausgabenummer5
Seiten (von - bis)388-392
Seitenumfang5
ISSN1359-2998
DOIs
PublikationsstatusVeröffentlicht - 21.07.2015

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  • Forschungsschwerpunkt: Gehirn, Hormone, Verhalten - Center for Brain, Behavior and Metabolism (CBBM)

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