Sexually dimorphic expression of prepro-orexin mRNA in the rat hypothalamus

Olaf Jöhren; Steffi J. Neidert; Marco Kummer; Peter Dominiak

doi:10.1016/S0196-9781(02)00052-9

Sexually dimorphic expression of prepro-orexin mRNA in the rat hypothalamus

Olaf Jöhren^*, Steffi J. Neidert, Marco Kummer, Peter Dominiak

^*Korrespondierende/r Autor/-in für diese Arbeit

Institut für Experimentelle und Klinische Pharmakologie und Toxikologie

Christian-Albrechts Universität zu Kiel

101 Zitate (Scopus)

Abstract

The neuropeptides orexin A and B are expressed in the lateral hypothalamic area and are involved in the regulation of energy homeostasis and arousal. Recent results showed gender differences in the expression of orexin receptor subtypes in rats. In the present study, we analyzed the mRNA expression of prepro-orexin (PPO) in the hypothalamus of male and female rats using quantitative real-time PCR. We found significantly higher levels of PPO mRNA in the hypothalamus of female rats compared to male rats. Our study indicates a sex-dependent regulation of hypothalamic PPO expression and suggests gender-specific functions of orexins.

Originalsprache	Englisch
Zeitschrift	Peptides
Jahrgang	23
Ausgabenummer	6
Seiten (von - bis)	1177-1180
Seitenumfang	4
ISSN	0196-9781
DOIs	https://doi.org/10.1016/S0196-9781(02)00052-9
Publikationsstatus	Veröffentlicht - 30.07.2002

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Forschungsschwerpunkt: Gehirn, Hormone, Verhalten - Center for Brain, Behavior and Metabolism (CBBM)

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10.1016/S0196-9781(02)00052-9

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title = "Sexually dimorphic expression of prepro-orexin mRNA in the rat hypothalamus",

abstract = "The neuropeptides orexin A and B are expressed in the lateral hypothalamic area and are involved in the regulation of energy homeostasis and arousal. Recent results showed gender differences in the expression of orexin receptor subtypes in rats. In the present study, we analyzed the mRNA expression of prepro-orexin (PPO) in the hypothalamus of male and female rats using quantitative real-time PCR. We found significantly higher levels of PPO mRNA in the hypothalamus of female rats compared to male rats. Our study indicates a sex-dependent regulation of hypothalamic PPO expression and suggests gender-specific functions of orexins.",

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AU - Jöhren, Olaf

AU - Neidert, Steffi J.

AU - Kummer, Marco

AU - Dominiak, Peter

PY - 2002/7/30

Y1 - 2002/7/30

N2 - The neuropeptides orexin A and B are expressed in the lateral hypothalamic area and are involved in the regulation of energy homeostasis and arousal. Recent results showed gender differences in the expression of orexin receptor subtypes in rats. In the present study, we analyzed the mRNA expression of prepro-orexin (PPO) in the hypothalamus of male and female rats using quantitative real-time PCR. We found significantly higher levels of PPO mRNA in the hypothalamus of female rats compared to male rats. Our study indicates a sex-dependent regulation of hypothalamic PPO expression and suggests gender-specific functions of orexins.

AB - The neuropeptides orexin A and B are expressed in the lateral hypothalamic area and are involved in the regulation of energy homeostasis and arousal. Recent results showed gender differences in the expression of orexin receptor subtypes in rats. In the present study, we analyzed the mRNA expression of prepro-orexin (PPO) in the hypothalamus of male and female rats using quantitative real-time PCR. We found significantly higher levels of PPO mRNA in the hypothalamus of female rats compared to male rats. Our study indicates a sex-dependent regulation of hypothalamic PPO expression and suggests gender-specific functions of orexins.

UR - https://www.scopus.com/pages/publications/0035996860

U2 - 10.1016/S0196-9781(02)00052-9

DO - 10.1016/S0196-9781(02)00052-9

M3 - Journal articles

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SN - 0196-9781

VL - 23

SP - 1177

EP - 1180

JO - Peptides

JF - Peptides

IS - 6

ER -

Sexually dimorphic expression of prepro-orexin mRNA in the rat hypothalamus

Abstract

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