Serine-to-asparagine substitution in the GyrA gene leads to quinolone resistance in moxifloxacin-exposed Chlamydia pneumoniae

Jan Rupp; Andreas Gebert; Werner Solbach; Matthias Maass

doi:10.1128/AAC.49.1.406-407.2005

Serine-to-asparagine substitution in the GyrA gene leads to quinolone resistance in moxifloxacin-exposed Chlamydia pneumoniae

Jan Rupp, Andreas Gebert, Werner Solbach, Matthias Maass^*

^*Korrespondierende/r Autor/-in für diese Arbeit

Institut für Anatomie

Paracelsus Medizinische Privatuniversität

14 Zitate (Scopus)

Abstract

Quinolone resistance of Chlamydia pneumoniae has not been described previously. Serial subcultures of C. pneumoniae under increasing moxifloxacin concentrations (0.0125 to 6.4 mg/liter) resulted in a 256-fold MIC increase compared to moxifloxacin-naive strains. GyrA gene sequencing revealed a novel point mutation with a Ser→Asn substitution. Subcultures under rifalazil and macrolides did not alter the respective MICs.

Originalsprache	Englisch
Zeitschrift	Antimicrobial Agents and Chemotherapy
Jahrgang	49
Ausgabenummer	1
Seiten (von - bis)	406-407
Seitenumfang	2
ISSN	0066-4804
DOIs	https://doi.org/10.1128/AAC.49.1.406-407.2005
Publikationsstatus	Veröffentlicht - 01.01.2005

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Serine-to-asparagine substitution in the GyrA gene leads to quinolone resistance in moxifloxacin-exposed Chlamydia pneumoniae

Abstract

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