Schizophrenia and apolipoprotein e gene polymorphism in Serbian population

Miljana Kecmanović; Valerija Dobričić; Rajna Dimitrijević; Dušan Keckarević; Dušanka Savić-Pavićević; Milica Keckarević-Marković; Maja Ivkovic; Stanka Romac

doi:10.3109/00207451003765956

Schizophrenia and apolipoprotein e gene polymorphism in Serbian population

Miljana Kecmanović, Valerija Dobričić, Rajna Dimitrijević, Dušan Keckarević, Dušanka Savić-Pavićević, Milica Keckarević-Marković, Maja Ivkovic, Stanka Romac

Institut für Neurogenetik

University of Belgrade

11 Zitate (Scopus)

Abstract

Apolipoprotein E (APOE) gene variants are associated with alterations in brain function and increased risk of Alzheimer's disease (AD) and conflicting results have been reported in schizophrenia. Our results showed no significant differences in APOE allele or genotype frequencies between the Serbian schizophrenic patients and control individuals. However, we observed a possible association between particular subtypes of schizophrenia and APOE ε3/ε3 genotype (p = .01221) and ε4 allele showed a tendency toward positive association with responding to typical neuroleptics. APOE genotypes have no major influence on risk of schizophrenia, treatment and response to conventional antipsychotics, and age of onset in schizophrenia.

Originalsprache	Englisch
Zeitschrift	International Journal of Neuroscience
Jahrgang	120
Ausgabenummer	7
Seiten (von - bis)	502-506
Seitenumfang	5
ISSN	0020-7454
DOIs	https://doi.org/10.3109/00207451003765956
Publikationsstatus	Veröffentlicht - 05.2010

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This work was supported by Serbian Sciences, grant # 143013 (2006–2010).

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title = "Schizophrenia and apolipoprotein e gene polymorphism in Serbian population",

abstract = "Apolipoprotein E (APOE) gene variants are associated with alterations in brain function and increased risk of Alzheimer's disease (AD) and conflicting results have been reported in schizophrenia. Our results showed no significant differences in APOE allele or genotype frequencies between the Serbian schizophrenic patients and control individuals. However, we observed a possible association between particular subtypes of schizophrenia and APOE ε3/ε3 genotype (p = .01221) and ε4 allele showed a tendency toward positive association with responding to typical neuroleptics. APOE genotypes have no major influence on risk of schizophrenia, treatment and response to conventional antipsychotics, and age of onset in schizophrenia.",

author = "Miljana Kecmanovi{\'c} and Valerija Dobri{\v c}i{\'c} and Rajna Dimitrijevi{\'c} and Du{\v s}an Keckarevi{\'c} and Du{\v s}anka Savi{\'c}-Pavi{\'c}evi{\'c} and Milica Keckarevi{\'c}-Markovi{\'c} and Maja Ivkovic and Stanka Romac",

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year = "2010",

month = may,

doi = "10.3109/00207451003765956",

language = "English",

volume = "120",

pages = "502--506",

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T1 - Schizophrenia and apolipoprotein e gene polymorphism in Serbian population

AU - Kecmanović, Miljana

AU - Dobričić, Valerija

AU - Dimitrijević, Rajna

AU - Keckarević, Dušan

AU - Savić-Pavićević, Dušanka

AU - Keckarević-Marković, Milica

AU - Ivkovic, Maja

AU - Romac, Stanka

N1 - Funding Information: This work was supported by Serbian Sciences, grant # 143013 (2006–2010).

PY - 2010/5

Y1 - 2010/5

N2 - Apolipoprotein E (APOE) gene variants are associated with alterations in brain function and increased risk of Alzheimer's disease (AD) and conflicting results have been reported in schizophrenia. Our results showed no significant differences in APOE allele or genotype frequencies between the Serbian schizophrenic patients and control individuals. However, we observed a possible association between particular subtypes of schizophrenia and APOE ε3/ε3 genotype (p = .01221) and ε4 allele showed a tendency toward positive association with responding to typical neuroleptics. APOE genotypes have no major influence on risk of schizophrenia, treatment and response to conventional antipsychotics, and age of onset in schizophrenia.

AB - Apolipoprotein E (APOE) gene variants are associated with alterations in brain function and increased risk of Alzheimer's disease (AD) and conflicting results have been reported in schizophrenia. Our results showed no significant differences in APOE allele or genotype frequencies between the Serbian schizophrenic patients and control individuals. However, we observed a possible association between particular subtypes of schizophrenia and APOE ε3/ε3 genotype (p = .01221) and ε4 allele showed a tendency toward positive association with responding to typical neuroleptics. APOE genotypes have no major influence on risk of schizophrenia, treatment and response to conventional antipsychotics, and age of onset in schizophrenia.

UR - https://www.scopus.com/pages/publications/77954195637

U2 - 10.3109/00207451003765956

DO - 10.3109/00207451003765956

M3 - Journal articles

C2 - 20583903

AN - SCOPUS:77954195637

SN - 0020-7454

VL - 120

SP - 502

EP - 506

JO - International Journal of Neuroscience

JF - International Journal of Neuroscience

IS - 7

ER -

Schizophrenia and apolipoprotein e gene polymorphism in Serbian population

Abstract

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