Scalp recorded direct current (DC) potential shifts associated with food intake in hungry humans

Beate Schmitt, Matthias Molle, Lisa Marshall, Manfred Hallschmid, Jan Born*

*Korrespondierende/r Autor/-in für diese Arbeit
10 Zitate (Scopus)

Abstract

In humans, eating is assumed to be regulated within a neuronal circuitry integrating hypothalamic 'feeding centers' with neocortical regions. Here, DC potentials were recorded in food deprived men to demonstrate a graded tuning of neocortical excitability in conjunction with meal ingestion. In the beginning of food ingestion a pronounced negative DC potential shift developed (P<0.01) which was replaced by a gradual positive potential shift reaching a maximum within 5 min after cessation of food intake (P<0.05). Both negative and positive shifts showed a widespread cortical distribution. The initial negative DC potential presumably reflecting increased depolarisation of apical cortical dendrites, may serve to facilitate eating behavior. The succeeding positivity points to a growing inhibitory influence on cortical processing with increasing satiety that may support termination of meal intake.

OriginalspracheEnglisch
ZeitschriftBehavioural Brain Research
Jahrgang119
Ausgabenummer1
Seiten (von - bis)85-92
Seitenumfang8
ISSN0166-4328
DOIs
PublikationsstatusVeröffentlicht - 15.02.2001

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