Role of gamma delta T cells in inflammatory bowel disease

Anja A. Kühl, Christoph Loddenkemper, Jürgen Westermann, Jörg C. Hoffmann*

*Korrespondierende/r Autor/-in für diese Arbeit
21 Zitate (Scopus)

Abstract

γδ T cells have previously been shown to play a protective role in various animal models of chronic inflammation (e.g., experimental autoimmune encephalomyelitis, collagen-induced arthritis, and non-obese diabetes). This immunoregulatory potential is exerted by synthesizing various anti-inflammatory cytokines and growth factors (e.g., transforming growth factor-β). As the normal balance between inflammatory and regulatory cytokines is perturbed in inflammatory bowel disease (IBD) a protective effect of γδ T cells seems likely. This notion is supported by our finding of increased mortality of rats with 2,4,6-trinitrobenzene sulfonic acid-induced colitis following γδ T cell depletion. In contrast, no effect was observed after depletion of γδ T cells in a Crohn's disease animal model with terminal ileitis (TNFΔARE mice). Therefore, future studies must further define where in the intestinal immune system γδ T cells exert their protective function and how this can be used in the treatment of IBD.

OriginalspracheEnglisch
ZeitschriftPathobiology
Jahrgang70
Ausgabenummer3
Seiten (von - bis)150-155
Seitenumfang6
ISSN1015-2008
DOIs
PublikationsstatusVeröffentlicht - 2003

Strategische Forschungsbereiche und Zentren

  • Forschungsschwerpunkt: Infektion und Entzündung - Zentrum für Infektions- und Entzündungsforschung Lübeck (ZIEL)

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