Role of ethnicity on the association of MAPT H1 haplotypes and subhaplotypes in Parkinson's disease

Susan Winkler; Inke R. König; Katja Lohmann-Hedrich; Peter Vieregge; Vladimir Kostic; Christine Klein

doi:10.1038/sj.ejhg.5201901

Role of ethnicity on the association of MAPT H1 haplotypes and subhaplotypes in Parkinson's disease

Susan Winkler, Inke R. König, Katja Lohmann-Hedrich, Peter Vieregge, Vladimir Kostic, Christine Klein^*

^*Korrespondierende/r Autor/-in für diese Arbeit

28 Zitate (Scopus)

Abstract

An association of the H1 haplotype and subhaplotypes in the microtubule-associated protein Tau (MAPT) gene with Parkinson's disease (PD) has been reported. To further evaluate their role in PD, we genotyped a sample set of 765 cases and controls consisting of two large European subgroups of German (n = 418) and Serbian (n = 347) origin for the MAPT haplotypes H1 and H2. The H1/H1 carriers were tested for three additional MAPT polymorphisms. In the Serbian sample, there was significant evidence (P = 0.0108) of an association of the H1/H1 genotype and PD. Surprisingly, in the German sample, we did not find significant differences in genotype or haplotype frequencies between patients and controls. These results suggest that the role of H1 haplotypes in the etiology of PD may be ethnically dependent.

Originalsprache	Englisch
Zeitschrift	European Journal of Human Genetics
Jahrgang	15
Ausgabenummer	11
Seiten (von - bis)	1163-1168
Seitenumfang	6
ISSN	1018-4813
DOIs	https://doi.org/10.1038/sj.ejhg.5201901
Publikationsstatus	Veröffentlicht - 01.11.2007

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This work was supported by a grant from the Deutsche Forschungsge-meinschaft, the Parkinson’s Disease Foundation/National Parkinson Foundation, the Bundesministerium für Bildung und Forschung, and the University Lübeck (all to CK). CK is supported by the VolkswagenStiftung. The authors have nothing to disclose

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title = "Role of ethnicity on the association of MAPT H1 haplotypes and subhaplotypes in Parkinson's disease",

abstract = "An association of the H1 haplotype and subhaplotypes in the microtubule-associated protein Tau (MAPT) gene with Parkinson's disease (PD) has been reported. To further evaluate their role in PD, we genotyped a sample set of 765 cases and controls consisting of two large European subgroups of German (n = 418) and Serbian (n = 347) origin for the MAPT haplotypes H1 and H2. The H1/H1 carriers were tested for three additional MAPT polymorphisms. In the Serbian sample, there was significant evidence (P = 0.0108) of an association of the H1/H1 genotype and PD. Surprisingly, in the German sample, we did not find significant differences in genotype or haplotype frequencies between patients and controls. These results suggest that the role of H1 haplotypes in the etiology of PD may be ethnically dependent.",

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AU - Winkler, Susan

AU - König, Inke R.

AU - Lohmann-Hedrich, Katja

AU - Vieregge, Peter

AU - Kostic, Vladimir

AU - Klein, Christine

PY - 2007/11/1

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N2 - An association of the H1 haplotype and subhaplotypes in the microtubule-associated protein Tau (MAPT) gene with Parkinson's disease (PD) has been reported. To further evaluate their role in PD, we genotyped a sample set of 765 cases and controls consisting of two large European subgroups of German (n = 418) and Serbian (n = 347) origin for the MAPT haplotypes H1 and H2. The H1/H1 carriers were tested for three additional MAPT polymorphisms. In the Serbian sample, there was significant evidence (P = 0.0108) of an association of the H1/H1 genotype and PD. Surprisingly, in the German sample, we did not find significant differences in genotype or haplotype frequencies between patients and controls. These results suggest that the role of H1 haplotypes in the etiology of PD may be ethnically dependent.

AB - An association of the H1 haplotype and subhaplotypes in the microtubule-associated protein Tau (MAPT) gene with Parkinson's disease (PD) has been reported. To further evaluate their role in PD, we genotyped a sample set of 765 cases and controls consisting of two large European subgroups of German (n = 418) and Serbian (n = 347) origin for the MAPT haplotypes H1 and H2. The H1/H1 carriers were tested for three additional MAPT polymorphisms. In the Serbian sample, there was significant evidence (P = 0.0108) of an association of the H1/H1 genotype and PD. Surprisingly, in the German sample, we did not find significant differences in genotype or haplotype frequencies between patients and controls. These results suggest that the role of H1 haplotypes in the etiology of PD may be ethnically dependent.

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Role of ethnicity on the association of MAPT H1 haplotypes and subhaplotypes in Parkinson's disease

Abstract

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