@article{d042e95ff120424089ef544a4b07a5cf,
title = "Resection of calcified aortic heart leaflets in vitro by Q-switched 2-μm microsecond laser radiation",
abstract = "Background Transcatheter aortic valve implantation (TAVI) can result in paravalvular leakage and stent deformation in the presence of severe calcification. This study was undertaken to determine the efficacy of laser-assisted resection of calcific aortic valve leaflets as a method to minimize the effects of calcium on perivalvular leakage during TAVI. Methods A Q-switched Tm:YAG laser emitting at a wavelength of 2.01-μm was used to evaluate the cutting efficiency on highly calcified human aortic leaflets in vitro (N-=-10). A pulse energy of 4.3-mJ, a pulse duration of 0.8-1-μs, and a repetition rate of 1-kHz were used. The radiation was transmitted via a 200-μm core diameter quartz fiber. Resection was performed in a fiber-tissue contact mode on water-covered samples in a dish. The remnant particles were analyzed with respect to quantity and size by light microscopy. Results A resection rate of 40.4-±-22.2-mg/min on highly calcified aortic leaflets was achieved. This corresponds to a cutting speed of approximately 1-cm/min; a laser dissection time of 3-min per leaflet is expected. The majority of the remnant particles (85.4\%) were <6-μm in diameter, with only 0.1\% exceeding 300-μm. Conclusions The Q-switched Tm:YAG laser system showed promising results in cutting calcified aortic valves, by transmitting sufficient energy through a small flexible fiber. Catheter-based removal of aortic valve calcification may help to improve TAVI technology. doi: 10.1111/jocs.12481 (J Card Surg 2015;30:157-162)",
author = "I. Rohde and Masch, \{J. M.\} and D. Theisen-Kunde and M. Marczynski-B{\"u}hlow and \{Bombien Quaden\}, R. and G. Lutter and R. Brinkmann",
year = "2015",
month = jan,
day = "1",
doi = "10.1111/jocs.12481",
language = "English",
volume = "30",
pages = "157--162",
journal = "Journal of Cardiac Surgery",
issn = "0886-0440",
publisher = "John Wiley and Sons Inc",
number = "2",
}
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