Research in practice: Diagnosis of subepidermal autoimmune bullous disorders

Titel in Übersetzung: Forschen für die Praxis: Diagnostik subepidermal blasenbildender Autoimmundermatosen

Enno Schmidt, Detlef Zillikens*

*Korrespondierende/r Autor/-in für diese Arbeit
20 Zitate (Scopus)

Abstract

Subepidermal autoimmune bullous disorders are a heterogeneous group of diseases that are associated with autoantibodies to hemidesmosomal proteins (pemphigoid group, epidermolysis bullosa acquisita) or epidermal/tissue transglutaminase (dermatitis herpetiformis). Characterization of the target antigens has led to the description of novel entities such as anti-p200 pemphigoid and has greatly facilitated the diagnosis of these diseases. Precise identification of target antigens is of therapeutic relevance since treatment options may greatly differ between these disorders. By the use of various in vitro and in vivo systems, the pathogenic relevance of autoantibodies to different hemidesmosomal constituents, including BP180 (type XVII collagen), laminin 332 (laminin 5), α6β4 integrin, and type VII collagen has been demonstrated. The translation of this basic scientific work has subsequently led to the development of specific autoantibody detection systems that are not only of diagnostic use but also allow the monitoring of circulating autoantibody levels during the course of the disease and thus are helpful in guiding treatment decisions in these patients.

Titel in ÜbersetzungForschen für die Praxis: Diagnostik subepidermal blasenbildender Autoimmundermatosen
OriginalspracheEnglisch
ZeitschriftJDDG - Journal of the German Society of Dermatology
Jahrgang7
Ausgabenummer4
Seiten (von - bis)296-300
Seitenumfang5
ISSN1610-0379
DOIs
PublikationsstatusVeröffentlicht - 04.2009

Strategische Forschungsbereiche und Zentren

  • Forschungsschwerpunkt: Infektion und Entzündung - Zentrum für Infektions- und Entzündungsforschung Lübeck (ZIEL)

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