Release of dynorphin-like immunoreactivity from rat anterior pituitary gland in vitro

W. Knepel*, M. Schwaninger

*Korrespondierende/r Autor/-in für diese Arbeit
7 Zitate (Scopus)

Abstract

Rat anterior pituitary quarters were incubated in vitro and the release of dynorphin A1-13-like immunoreactivity (Dyn A1-13-IR) into the incubation medium was studied. An elevation of the potassium concentration of the incubation medium to 40 mmol/l increased the release of Dyn A1-13-IR in a calcium-dependent manner. Addition of luteinizing hormone-releasing hormone (LHRH) stimulated the release of Dyn A1-13-IR in a dose-dependent manner. The LHRH-induced release of Dyn A1-13-IR was almost completely prevented by omission of calcium ions from the incubation medium or by addition of the LHRH-antagonist d-pGlu1, d-Phe2, d-Trp3,6-LHRH. This is the first demonstration that dynorphin-like immunoreactivity can be released from the rat adenohypophysis through calcium-dependent mechanisms by both high potassium concentration and receptor-mediated stimulation.

OriginalspracheEnglisch
ZeitschriftNaunyn-Schmiedebergs Archives of Pharmacology
Jahrgang329
Ausgabenummer1
Seiten (von - bis)94-96
Seitenumfang3
ISSN0028-1298
DOIs
PublikationsstatusVeröffentlicht - 03.1985

Strategische Forschungsbereiche und Zentren

  • Forschungsschwerpunkt: Infektion und Entzündung - Zentrum für Infektions- und Entzündungsforschung Lübeck (ZIEL)

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