Reduced tissue immigration of monocytes by neuropeptide Y during endotoxemia is associated with Y2 receptor activation

Heike Nave*, Sammy Bedoui, Frank Moenter, Jan Steffens, Melanie Felies, Thomas Gebhardt, Rainer H. Straub, Reinhard Pabst, Mira Dimitrijevic, Stanislava Stanojevic, Stephan Von Hörsten

*Korrespondierende/r Autor/-in für diese Arbeit
41 Zitate (Scopus)

Abstract

Neuropeptide Y (NPY) increases survival in experimental septic shock, which might be mediated by cardiovascular and/or immunological effects. To study the latter hypothesis, we monitored blood leukocyte subsets over 96 h after intravenous (i.v.) application of LPS in chronically i.v.-cannulated rats. LPS induced a dramatic leukopenia at 4 h after challenge, which was blunted in NPY-treated animals by stabilizing granulocyte and T-lymphocyte numbers. In addition, NPY treatment prevented tissue immigration of monocytes at early time points and consecutively mobilized activated monocytes from the third day after challenge. RT-PCR and in vitro adhesion studies provided evidence for a NPY Y2 receptor-mediated effect on monocytes. Thus, NPY treatment has profound receptor-specific effects on the migration and adhesion of leukocytes under endotoxemic conditions.

OriginalspracheEnglisch
ZeitschriftJournal of Neuroimmunology
Jahrgang155
Ausgabenummer1-2
Seiten (von - bis)1-12
Seitenumfang12
ISSN0165-5728
DOIs
PublikationsstatusVeröffentlicht - 01.10.2004
Extern publiziertJa

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  • Forschungsschwerpunkt: Gehirn, Hormone, Verhalten - Center for Brain, Behavior and Metabolism (CBBM)

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