Reduced memory B cells in patients with hyper IgE syndrome

C. Speckmann; A. Enders; C. Woellner; D. Thiel; A. Rensing-Ehl; M. Schlesier; J. Rohr; T. Jakob; E. Oswald; M. V. Kopp; O. Sanal; J. Litzman; A. Plebani; M. C. Pietrogrande; J. L. Franco; T. Espanol; B. Grimbacher; S. Ehl

doi:10.1016/j.clim.2008.08.002

Reduced memory B cells in patients with hyper IgE syndrome

C. Speckmann, A. Enders, C. Woellner, D. Thiel, A. Rensing-Ehl, M. Schlesier, J. Rohr, T. Jakob, E. Oswald, M. V. Kopp, O. Sanal, J. Litzman, A. Plebani, M. C. Pietrogrande, J. L. Franco, T. Espanol, B. Grimbacher, S. Ehl^*

^*Korrespondierende/r Autor/-in für diese Arbeit

Klinik für Kinder- und Jugendmedizin

63 Zitate (Scopus)

Abstract

Dominant-negative mutations in STAT-3 have recently been found in the majority of patients with sporadic or autosomal-dominant hyper IgE syndrome (HIES). Since STAT-3 plays a role in B cell development and differentiation, we analyzed memory B cells in 20 patients with HIES, 17 of which had STAT-3 mutations. All but four patients had reduced non-switched and/or class-switched memory B cells. No reduction in these B cell populations was found in 16 atopic dermatitis patients with IgE levels above 1000 KU/L. There was no correlation between the reduction of memory B cells and the ability to produce specific antibodies. Moreover, there was no correlation between the percentage of memory B cells and the infection history. Analysis of memory B cells can be useful in distinguishing patients with suspected HIES from patients with atopic disease, but probably fails to identify patients who are at high risk of infection.

Originalsprache	Englisch
Zeitschrift	Clinical Immunology
Jahrgang	129
Ausgabenummer	3
Seiten (von - bis)	448-454
Seitenumfang	7
ISSN	1521-6616
DOIs	https://doi.org/10.1016/j.clim.2008.08.002
Publikationsstatus	Veröffentlicht - 12.2008

Fördermittel

S.E. is supported by the SFB620 (Project A4). J.L.F. is supported by the Grant colciencias 1115-04-12014. B.G. is supported by DFG grant GR1617/3 and the European Union grants SP23-CT-2005-0064110 and MEXT-CT-2006-042316.

UN SDGs

Dieser Output leistet einen Beitrag zu folgendem(n) Ziel(en) für nachhaltige Entwicklung

SDG 3 – Gesundheit und Wohlergehen

Strategische Forschungsbereiche und Zentren

Forschungsschwerpunkt: Gehirn, Hormone, Verhalten - Center for Brain, Behavior and Metabolism (CBBM)

Dokumente

10.1016/j.clim.2008.08.002

Weitere Links

Link to publication in Scopus

Zitieren

Speckmann, C., Enders, A., Woellner, C., Thiel, D., Rensing-Ehl, A., Schlesier, M., Rohr, J., Jakob, T., Oswald, E., Kopp, M. V., Sanal, O., Litzman, J., Plebani, A., Pietrogrande, M. C., Franco, J. L., Espanol, T., Grimbacher, B., & Ehl, S. (2008). Reduced memory B cells in patients with hyper IgE syndrome. Clinical Immunology, 129(3), 448-454. https://doi.org/10.1016/j.clim.2008.08.002

@article{985685fa33f64acba47b3a4b9b8bfa52,

title = "Reduced memory B cells in patients with hyper IgE syndrome",

abstract = "Dominant-negative mutations in STAT-3 have recently been found in the majority of patients with sporadic or autosomal-dominant hyper IgE syndrome (HIES). Since STAT-3 plays a role in B cell development and differentiation, we analyzed memory B cells in 20 patients with HIES, 17 of which had STAT-3 mutations. All but four patients had reduced non-switched and/or class-switched memory B cells. No reduction in these B cell populations was found in 16 atopic dermatitis patients with IgE levels above 1000 KU/L. There was no correlation between the reduction of memory B cells and the ability to produce specific antibodies. Moreover, there was no correlation between the percentage of memory B cells and the infection history. Analysis of memory B cells can be useful in distinguishing patients with suspected HIES from patients with atopic disease, but probably fails to identify patients who are at high risk of infection.",

author = "C. Speckmann and A. Enders and C. Woellner and D. Thiel and A. Rensing-Ehl and M. Schlesier and J. Rohr and T. Jakob and E. Oswald and Kopp, \{M. V.\} and O. Sanal and J. Litzman and A. Plebani and Pietrogrande, \{M. C.\} and Franco, \{J. L.\} and T. Espanol and B. Grimbacher and S. Ehl",

note = "Funding Information: S.E. is supported by the SFB620 (Project A4). J.L.F. is supported by the Grant colciencias 1115-04-12014. B.G. is supported by DFG grant GR1617/3 and the European Union grants SP23-CT-2005-0064110 and MEXT-CT-2006-042316. Copyright: Copyright 2011 Elsevier B.V., All rights reserved.",

year = "2008",

month = dec,

doi = "10.1016/j.clim.2008.08.002",

language = "English",

volume = "129",

pages = "448--454",

journal = "Clinical Immunology",

issn = "1521-6616",

publisher = "Academic Press Inc.",

number = "3",

}

Speckmann, C, Enders, A, Woellner, C, Thiel, D, Rensing-Ehl, A, Schlesier, M, Rohr, J, Jakob, T, Oswald, E, Kopp, MV, Sanal, O, Litzman, J, Plebani, A, Pietrogrande, MC, Franco, JL, Espanol, T, Grimbacher, B & Ehl, S 2008, 'Reduced memory B cells in patients with hyper IgE syndrome', Clinical Immunology, Jg. 129, Nr. 3, S. 448-454. https://doi.org/10.1016/j.clim.2008.08.002

TY - JOUR

T1 - Reduced memory B cells in patients with hyper IgE syndrome

AU - Speckmann, C.

AU - Enders, A.

AU - Woellner, C.

AU - Thiel, D.

AU - Rensing-Ehl, A.

AU - Schlesier, M.

AU - Rohr, J.

AU - Jakob, T.

AU - Oswald, E.

AU - Kopp, M. V.

AU - Sanal, O.

AU - Litzman, J.

AU - Plebani, A.

AU - Pietrogrande, M. C.

AU - Franco, J. L.

AU - Espanol, T.

AU - Grimbacher, B.

AU - Ehl, S.

N1 - Funding Information: S.E. is supported by the SFB620 (Project A4). J.L.F. is supported by the Grant colciencias 1115-04-12014. B.G. is supported by DFG grant GR1617/3 and the European Union grants SP23-CT-2005-0064110 and MEXT-CT-2006-042316. Copyright: Copyright 2011 Elsevier B.V., All rights reserved.

PY - 2008/12

Y1 - 2008/12

N2 - Dominant-negative mutations in STAT-3 have recently been found in the majority of patients with sporadic or autosomal-dominant hyper IgE syndrome (HIES). Since STAT-3 plays a role in B cell development and differentiation, we analyzed memory B cells in 20 patients with HIES, 17 of which had STAT-3 mutations. All but four patients had reduced non-switched and/or class-switched memory B cells. No reduction in these B cell populations was found in 16 atopic dermatitis patients with IgE levels above 1000 KU/L. There was no correlation between the reduction of memory B cells and the ability to produce specific antibodies. Moreover, there was no correlation between the percentage of memory B cells and the infection history. Analysis of memory B cells can be useful in distinguishing patients with suspected HIES from patients with atopic disease, but probably fails to identify patients who are at high risk of infection.

AB - Dominant-negative mutations in STAT-3 have recently been found in the majority of patients with sporadic or autosomal-dominant hyper IgE syndrome (HIES). Since STAT-3 plays a role in B cell development and differentiation, we analyzed memory B cells in 20 patients with HIES, 17 of which had STAT-3 mutations. All but four patients had reduced non-switched and/or class-switched memory B cells. No reduction in these B cell populations was found in 16 atopic dermatitis patients with IgE levels above 1000 KU/L. There was no correlation between the reduction of memory B cells and the ability to produce specific antibodies. Moreover, there was no correlation between the percentage of memory B cells and the infection history. Analysis of memory B cells can be useful in distinguishing patients with suspected HIES from patients with atopic disease, but probably fails to identify patients who are at high risk of infection.

UR - https://www.scopus.com/pages/publications/55549117115

U2 - 10.1016/j.clim.2008.08.002

DO - 10.1016/j.clim.2008.08.002

M3 - Journal articles

C2 - 18835223

AN - SCOPUS:55549117115

SN - 1521-6616

VL - 129

SP - 448

EP - 454

JO - Clinical Immunology

JF - Clinical Immunology

IS - 3

ER -

Reduced memory B cells in patients with hyper IgE syndrome

Abstract

Fördermittel

UN SDGs

Strategische Forschungsbereiche und Zentren

Dokumente

Weitere Links

Fingerprint

Zitieren