Recognition of autologous and allogeneic lymphocytes and tumor cells by human natural killer cells

M. Benczur; G. Sármay; T. Laskay; E. Gyódi; G. Gy Petrányi; J. Gergely

doi:10.1016/0161-5890(82)90301-7

Recognition of autologous and allogeneic lymphocytes and tumor cells by human natural killer cells

M. Benczur^*, G. Sármay, T. Laskay, E. Gyódi, G. Gy Petrányi, J. Gergely

^*Korrespondierende/r Autor/-in für diese Arbeit

3 Zitate (Scopus)

Abstract

The shedding of the mobile Fc receptor (FcR₁) and the depletion of the immobile Fc receptor (FcR₁₁) bearing human lymphocytes revealed that human natural killer cells belong to the FcR₁₁-bearing population. Anti-beta-2-microglobulin treatment of the effector cells decreased natural cytotoxicity against some target cells and the detectability of H LA antigens, indicating that histocompatibility antigens or related structures may be involved in natural cytotoxicity. Using a panel of 29 autologous and allogenic PHA-stimulated target cells and peripheral lymphocytes from the same donors as the effector cells, distinct cytotoxic responses against allogeneic and autologous target cells were observed. A computer analysis of selective natural cytotoxicity distinguished seven different groups of target cells that may represent common structures for NK. recognition.

Originalsprache	Englisch
Zeitschrift	Molecular Immunology
Jahrgang	19
Ausgabenummer	10
Seiten (von - bis)	1331-1340
Seitenumfang	10
ISSN	0161-5890
DOIs	https://doi.org/10.1016/0161-5890(82)90301-7
Publikationsstatus	Veröffentlicht - 01.01.1982

Strategische Forschungsbereiche und Zentren

Forschungsschwerpunkt: Infektion und Entzündung - Zentrum für Infektions- und Entzündungsforschung Lübeck (ZIEL)

Zugriff auf Dokument

10.1016/0161-5890(82)90301-7

Andere Dateien und Links

Link to publication in Scopus

Zitieren

@article{c63e9495d6d9489089932edac7bd1e73,

title = "Recognition of autologous and allogeneic lymphocytes and tumor cells by human natural killer cells",

abstract = "The shedding of the mobile Fc receptor (FcR1) and the depletion of the immobile Fc receptor (FcR11) bearing human lymphocytes revealed that human natural killer cells belong to the FcR11-bearing population. Anti-beta-2-microglobulin treatment of the effector cells decreased natural cytotoxicity against some target cells and the detectability of H LA antigens, indicating that histocompatibility antigens or related structures may be involved in natural cytotoxicity. Using a panel of 29 autologous and allogenic PHA-stimulated target cells and peripheral lymphocytes from the same donors as the effector cells, distinct cytotoxic responses against allogeneic and autologous target cells were observed. A computer analysis of selective natural cytotoxicity distinguished seven different groups of target cells that may represent common structures for NK. recognition.",

author = "M. Benczur and G. S{\'a}rmay and T. Laskay and E. Gy{\'o}di and Petr{\'a}nyi, {G. Gy} and J. Gergely",

year = "1982",

month = jan,

day = "1",

doi = "10.1016/0161-5890(82)90301-7",

language = "English",

volume = "19",

pages = "1331--1340",

journal = "Molecular Immunology",

issn = "0161-5890",

number = "10",

}

TY - JOUR

T1 - Recognition of autologous and allogeneic lymphocytes and tumor cells by human natural killer cells

AU - Benczur, M.

AU - Sármay, G.

AU - Laskay, T.

AU - Gyódi, E.

AU - Petrányi, G. Gy

AU - Gergely, J.

PY - 1982/1/1

Y1 - 1982/1/1

N2 - The shedding of the mobile Fc receptor (FcR1) and the depletion of the immobile Fc receptor (FcR11) bearing human lymphocytes revealed that human natural killer cells belong to the FcR11-bearing population. Anti-beta-2-microglobulin treatment of the effector cells decreased natural cytotoxicity against some target cells and the detectability of H LA antigens, indicating that histocompatibility antigens or related structures may be involved in natural cytotoxicity. Using a panel of 29 autologous and allogenic PHA-stimulated target cells and peripheral lymphocytes from the same donors as the effector cells, distinct cytotoxic responses against allogeneic and autologous target cells were observed. A computer analysis of selective natural cytotoxicity distinguished seven different groups of target cells that may represent common structures for NK. recognition.

AB - The shedding of the mobile Fc receptor (FcR1) and the depletion of the immobile Fc receptor (FcR11) bearing human lymphocytes revealed that human natural killer cells belong to the FcR11-bearing population. Anti-beta-2-microglobulin treatment of the effector cells decreased natural cytotoxicity against some target cells and the detectability of H LA antigens, indicating that histocompatibility antigens or related structures may be involved in natural cytotoxicity. Using a panel of 29 autologous and allogenic PHA-stimulated target cells and peripheral lymphocytes from the same donors as the effector cells, distinct cytotoxic responses against allogeneic and autologous target cells were observed. A computer analysis of selective natural cytotoxicity distinguished seven different groups of target cells that may represent common structures for NK. recognition.

UR - http://www.scopus.com/inward/record.url?scp=0019992672&partnerID=8YFLogxK

U2 - 10.1016/0161-5890(82)90301-7

DO - 10.1016/0161-5890(82)90301-7

M3 - Journal articles

C2 - 6757725

AN - SCOPUS:0019992672

SN - 0161-5890

VL - 19

SP - 1331

EP - 1340

JO - Molecular Immunology

JF - Molecular Immunology

IS - 10

ER -

Recognition of autologous and allogeneic lymphocytes and tumor cells by human natural killer cells

Abstract

Strategische Forschungsbereiche und Zentren

Zugriff auf Dokument

Andere Dateien und Links

Fingerprint

Zitieren