Recognition of autologous and allogeneic lymphocytes and tumor cells by human natural killer cells

M. Benczur*, G. Sármay, T. Laskay, E. Gyódi, G. Gy Petrányi, J. Gergely

*Korrespondierende/r Autor/-in für diese Arbeit
3 Zitate (Scopus)

Abstract

The shedding of the mobile Fc receptor (FcR1) and the depletion of the immobile Fc receptor (FcR11) bearing human lymphocytes revealed that human natural killer cells belong to the FcR11-bearing population. Anti-beta-2-microglobulin treatment of the effector cells decreased natural cytotoxicity against some target cells and the detectability of H LA antigens, indicating that histocompatibility antigens or related structures may be involved in natural cytotoxicity. Using a panel of 29 autologous and allogenic PHA-stimulated target cells and peripheral lymphocytes from the same donors as the effector cells, distinct cytotoxic responses against allogeneic and autologous target cells were observed. A computer analysis of selective natural cytotoxicity distinguished seven different groups of target cells that may represent common structures for NK. recognition.

OriginalspracheEnglisch
ZeitschriftMolecular Immunology
Jahrgang19
Ausgabenummer10
Seiten (von - bis)1331-1340
Seitenumfang10
ISSN0161-5890
DOIs
PublikationsstatusVeröffentlicht - 01.01.1982

Strategische Forschungsbereiche und Zentren

  • Forschungsschwerpunkt: Infektion und Entzündung - Zentrum für Infektions- und Entzündungsforschung Lübeck (ZIEL)

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