Abstract
Photocoagulation is a treatment modality for several retinal diseases. Intra- and inter-individual variations of the retinal absorption as well as ocular transmission and light scattering makes it impossible to achieve a uniform effective exposure with one set of laser parameters. To guarantee a uniform damage throughout the therapy a real-time control is highly requested. Here, an approach to realize a real-time optical feedback using dynamic speckle analysis in-vivo is presented. A 532 nm continuous wave Nd:YAG laser is used for coagulation. During coagulation, speckle dynamics are monitored by a coherent object illumination using a 633 nm diode laser and analyzed by a CMOS camera with a frame rate up to 1 kHz. An algorithm is presented that can discriminate between different categories of retinal pigment epithelial damage ex-vivo in enucleated porcine eyes and that seems to be robust to noise in-vivo. Tissue changes in rabbits during retinal coagulation could be observed for different lesion strengths. This algorithm can run on a FPGA and is able to calculate a feedback value which is correlated to the thermal and coagulation induced tissue motion and thus the achieved damage.
Originalsprache | Englisch |
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Titel | Novel Biophotonics Techniques and Applications IV |
Redakteure/-innen | Arjen Amelink |
Band | 10413 |
Herausgeber (Verlag) | SPIE |
Erscheinungsdatum | 28.07.2017 |
Seiten | 1041308-1-7 |
ISBN (Print) | 978-151061284-6 |
DOIs | |
Publikationsstatus | Veröffentlicht - 28.07.2017 |
Veranstaltung | EUROPEAN CONFERENCES ON BIOMEDICAL OPTICS - ICM-International Congress Center Munich, Munich, Deutschland Dauer: 25.06.2017 → 29.06.2017 Konferenznummer: 137548 |
Strategische Forschungsbereiche und Zentren
- Forschungsschwerpunkt: Biomedizintechnik