Real Time Speckle Monitoring to Control Retinal Photocoagulation

Abstract

Photocoagulation is a treatment modality for several retinal diseases. Intra- and inter-individual variations of the retinal absorption as well as ocular transmission and light scattering makes it impossible to achieve a uniform effective exposure with one set of laser parameters. To guarantee a uniform damage throughout the therapy a real-time control is highly requested. Here, an approach to realize a real-time optical feedback using dynamic speckle analysis in-vivo is presented. A 532 nm continuous wave Nd:YAG laser is used for coagulation. During coagulation, speckle dynamics are monitored by a coherent object illumination using a 633 nm diode laser and analyzed by a CMOS camera with a frame rate up to 1 kHz. An algorithm is presented that can discriminate between different categories of retinal pigment epithelial damage ex-vivo in enucleated porcine eyes and that seems to be robust to noise in-vivo. Tissue changes in rabbits during retinal coagulation could be observed for different lesion strengths. This algorithm can run on a FPGA and is able to calculate a feedback value which is correlated to the thermal and coagulation induced tissue motion and thus the achieved damage.
OriginalspracheEnglisch
TitelNovel Biophotonics Techniques and Applications IV
Redakteure/-innenArjen Amelink
Band10413
Herausgeber (Verlag)SPIE
Erscheinungsdatum28.07.2017
Seiten1041308-1-7
ISBN (Print)978-151061284-6
DOIs
PublikationsstatusVeröffentlicht - 28.07.2017
VeranstaltungEUROPEAN CONFERENCES ON BIOMEDICAL OPTICS
- ICM-International Congress Center Munich, Munich, Deutschland
Dauer: 25.06.201729.06.2017
Konferenznummer: 137548

Strategische Forschungsbereiche und Zentren

  • Forschungsschwerpunkt: Biomedizintechnik

Fingerprint

Untersuchen Sie die Forschungsthemen von „Real Time Speckle Monitoring to Control Retinal Photocoagulation“. Zusammen bilden sie einen einzigartigen Fingerprint.

Zitieren