Re-irradiation with 36 Gy (1.5 Gy twice daily) plus paclitaxel for advanced recurrent and previously irradiated SCCHN is feasible

Dirk Rades*, Tobias Bartscht, Christian Idel, Samer G. Hakim

*Korrespondierende/r Autor/-in für diese Arbeit
2 Zitate (Scopus)

Abstract

Background/Aim: Many patients developing a loco-regional recurrence of squamous cell carcinoma of head and neck (SCCHN) have a poor prognosis. Often, recurrences are unresectable, and patients require a second course of radiotherapy or chemoradiation. We present an approach of chemoradiation including mainly 30 Gy of radiotherapy (1.5 Gy twice daily) plus concurrent paclitaxel. To further improve the prognoses of these patients, we increased the radiation dose from 30 to 36 Gy. Patients and Methods: In four patients with recurrent and previously irradiated SCCHN (60-70 Gy) chemoradiation was carried out using 36 Gy (1.5 Gy twice daily) and concurrent paclitaxel (4-5 times 20-25 mg/m2). Results: One-year loco-regional control rates were 75% inside and 67% outside re-irradiated regions. One-year survival was 50%, and median survival time 11 months. Toxicities were mild (grade 0-2). Conclusion: Re-irradiation with 36 Gy (1.5 Gy twice daily) plus paclitaxel appears feasible and may lead to promising outcomes. This study is preceding a phase I trial.

OriginalspracheEnglisch
ZeitschriftAnticancer Research
Jahrgang38
Ausgabenummer1
Seiten (von - bis)519-523
Seitenumfang5
ISSN0250-7005
DOIs
PublikationsstatusVeröffentlicht - 01.2018

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