Rare human IFNG variants

Thorsten Thye; Christa Ehmen; Christopher D. Intemann; Margaret Amanua Chinbuah; Andreas Ziegler; Rolf D. Horstmann; Christian G. Meyer

doi:10.1089/jir.2009.0042

Rare human IFNG variants

Thorsten Thye
, Christa Ehmen
, Christopher D. Intemann
, Margaret Amanua Chinbuah
, Andreas Ziegler
, Rolf D. Horstmann
, Christian G. Meyer

Institut für Medizinische Biometrie und Statistik

Bernhard Nocht Institute for Tropical Medicine

Abstract

After the identification of the human interferon-gamma (IFNG) variant G54D (c.287G>A, ss105106770) in DNA samples from Ghana, West Africa, systematic mutation screening of IFNG by the LightCycler®-based procedure of high-resolution melting (HRM) revealed additional rare mutations. All variants occurred heterozygously only and were confirmed either by their detection in other individuals and/or by repeated DNA sequencing of independent PCR products.

Originalsprache	Englisch
Zeitschrift	Journal of Interferon and Cytokine Research
Jahrgang	30
Ausgabenummer	4
Seiten (von - bis)	219-222
Seitenumfang	4
ISSN	1079-9907
DOIs	https://doi.org/10.1089/jir.2009.0042
Publikationsstatus	Veröffentlicht - 01.04.2010

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title = "Rare human IFNG variants",

abstract = "After the identification of the human interferon-gamma (IFNG) variant G54D (c.287G>A, ss105106770) in DNA samples from Ghana, West Africa, systematic mutation screening of IFNG by the LightCycler{\textregistered}-based procedure of high-resolution melting (HRM) revealed additional rare mutations. All variants occurred heterozygously only and were confirmed either by their detection in other individuals and/or by repeated DNA sequencing of independent PCR products.",

author = "Thorsten Thye and Christa Ehmen and Intemann, \{Christopher D.\} and Chinbuah, \{Margaret Amanua\} and Andreas Ziegler and Horstmann, \{Rolf D.\} and Meyer, \{Christian G.\}",

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AU - Thye, Thorsten

AU - Ehmen, Christa

AU - Intemann, Christopher D.

AU - Chinbuah, Margaret Amanua

AU - Ziegler, Andreas

AU - Horstmann, Rolf D.

AU - Meyer, Christian G.

PY - 2010/4/1

Y1 - 2010/4/1

N2 - After the identification of the human interferon-gamma (IFNG) variant G54D (c.287G>A, ss105106770) in DNA samples from Ghana, West Africa, systematic mutation screening of IFNG by the LightCycler®-based procedure of high-resolution melting (HRM) revealed additional rare mutations. All variants occurred heterozygously only and were confirmed either by their detection in other individuals and/or by repeated DNA sequencing of independent PCR products.

AB - After the identification of the human interferon-gamma (IFNG) variant G54D (c.287G>A, ss105106770) in DNA samples from Ghana, West Africa, systematic mutation screening of IFNG by the LightCycler®-based procedure of high-resolution melting (HRM) revealed additional rare mutations. All variants occurred heterozygously only and were confirmed either by their detection in other individuals and/or by repeated DNA sequencing of independent PCR products.

UR - https://www.scopus.com/pages/publications/77952522092

U2 - 10.1089/jir.2009.0042

DO - 10.1089/jir.2009.0042

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AN - SCOPUS:77952522092

SN - 1079-9907

VL - 30

SP - 219

EP - 222

JO - Journal of Interferon and Cytokine Research

JF - Journal of Interferon and Cytokine Research

IS - 4

ER -

Rare human IFNG variants

Abstract

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