Rare human IFNG variants

Thorsten Thye; Christa Ehmen; Christopher D. Intemann; Margaret Amanua Chinbuah; Andreas Ziegler; Rolf D. Horstmann; Christian G. Meyer

doi:10.1089/jir.2009.0042

Rare human IFNG variants

Thorsten Thye, Christa Ehmen, Christopher D. Intemann, Margaret Amanua Chinbuah, Andreas Ziegler, Rolf D. Horstmann, Christian G. Meyer

Institut für Medizinische Biometrie und Statistik

Bernhard Nocht Institute for Tropical Medicine

Abstract

After the identification of the human interferon-gamma (IFNG) variant G54D (c.287G>A, ss105106770) in DNA samples from Ghana, West Africa, systematic mutation screening of IFNG by the LightCycler®-based procedure of high-resolution melting (HRM) revealed additional rare mutations. All variants occurred heterozygously only and were confirmed either by their detection in other individuals and/or by repeated DNA sequencing of independent PCR products.

Originalsprache	Englisch
Zeitschrift	Journal of Interferon and Cytokine Research
Jahrgang	30
Ausgabenummer	4
Seiten (von - bis)	219-222
Seitenumfang	4
ISSN	1079-9907
DOIs	https://doi.org/10.1089/jir.2009.0042
Publikationsstatus	Veröffentlicht - 01.04.2010

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10.1089/jir.2009.0042

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title = "Rare human IFNG variants",

abstract = "After the identification of the human interferon-gamma (IFNG) variant G54D (c.287G>A, ss105106770) in DNA samples from Ghana, West Africa, systematic mutation screening of IFNG by the LightCycler{\textregistered}-based procedure of high-resolution melting (HRM) revealed additional rare mutations. All variants occurred heterozygously only and were confirmed either by their detection in other individuals and/or by repeated DNA sequencing of independent PCR products.",

author = "Thorsten Thye and Christa Ehmen and Intemann, \{Christopher D.\} and Chinbuah, \{Margaret Amanua\} and Andreas Ziegler and Horstmann, \{Rolf D.\} and Meyer, \{Christian G.\}",

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AU - Thye, Thorsten

AU - Ehmen, Christa

AU - Intemann, Christopher D.

AU - Chinbuah, Margaret Amanua

AU - Ziegler, Andreas

AU - Horstmann, Rolf D.

AU - Meyer, Christian G.

PY - 2010/4/1

Y1 - 2010/4/1

N2 - After the identification of the human interferon-gamma (IFNG) variant G54D (c.287G>A, ss105106770) in DNA samples from Ghana, West Africa, systematic mutation screening of IFNG by the LightCycler®-based procedure of high-resolution melting (HRM) revealed additional rare mutations. All variants occurred heterozygously only and were confirmed either by their detection in other individuals and/or by repeated DNA sequencing of independent PCR products.

AB - After the identification of the human interferon-gamma (IFNG) variant G54D (c.287G>A, ss105106770) in DNA samples from Ghana, West Africa, systematic mutation screening of IFNG by the LightCycler®-based procedure of high-resolution melting (HRM) revealed additional rare mutations. All variants occurred heterozygously only and were confirmed either by their detection in other individuals and/or by repeated DNA sequencing of independent PCR products.

UR - https://www.scopus.com/pages/publications/77952522092

U2 - 10.1089/jir.2009.0042

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AN - SCOPUS:77952522092

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JO - Journal of Interferon and Cytokine Research

JF - Journal of Interferon and Cytokine Research

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ER -

Rare human IFNG variants

Abstract

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