Radiosurgery with 20 Gy provides better local contol of 1-3 brain metastases from breast cancer than with lower doses

Dirk Rades*, Stefan Huttenlocher, Volker Rudat, Dagmar Hornung, Oliver Blanck, Pham Cam Phuong, Mai Trong Khoa, Steven E. Schild, Dorothea Fischer

*Korrespondierende/r Autor/-in für diese Arbeit
22 Zitate (Scopus)

Abstract

Patients and Methods: Patients receiving 20 Gy (n=20) were compared to those receiving 16-18.5 Gy (n=10) for local control, distant brain control and overall survival. Seven other variables were also evaluated.

Aim: To determine the optimal dose of radiosurgery-alone for patients with 1-3 cerebral metastases from breast cancer.

Results: Radiosurgery dose achieved significance on univariate (p=0.002; log-rank and Wilcoxon test) and multivariate analysis (p=0.004) of local control. Twelve-month local control rates were 94% after 20 Gy and 48% after 16-18.5 Gy. On univariate analysis of distant brain control, radiosurgery dose was not a significant factor, with 12-month rates of 73% and 60%, respectively. Regarding overall survival, radiosurgery dose was of borderline significance (p=0.059; Wilcoxon test). Twelve-month overall survival rates were 75% and 40%, respectively. On Cox regression analysis, radiosurgery dose exhibited a trend for improving survival (p=0.10).

Conclusion: Radiosurgery with 20 Gy resulted in significantly better local control and led to a trend towards improved overall survival compared to treatment with 16-18.5 Gy.

OriginalspracheEnglisch
ZeitschriftAnticancer Research
Jahrgang35
Ausgabenummer1
Seiten (von - bis)333-336
Seitenumfang4
ISSN0250-7005
PublikationsstatusVeröffentlicht - 01.01.2015

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