Radiation therapy for metastatic spinal cord compression in patients with hepatocellular carcinoma

Dirk Rades*, Markus Dahlke, Stefan Janssen, Niklas Gebauer, Tobias Bartscht

*Korrespondierende/r Autor/-in für diese Arbeit
4 Zitate (Scopus)

Abstract

Aim: This is the first study to investigate patients with metastatic spinal cord compression (MSCC) from hepatocellular carcinoma (HCC). Patients and Methods: Eight patients were analyzed with regard to survival and motor dysfunction. Results: Out of seven factors (age, affected vertebrae, ambulatory status, bone lesions, other distant metastases, time developing motor dysfunction, performance score) ambulatory status (p=0.005) and distant metastases (p=0.032) had a significant influence on survival. Both factors were used as a predictive tool (points: not ambulatory 0, ambulatory 1, distant metastases 0, no distant metastases 1). Total scores were 0, 1 or 2 points. Threemonth survival rates were 0%, 67% and 100%, six-month survival rates 0%, 0% and 100%. Progression of motor dysfunction was prevented in 63% of patients; time developing motor deficits showed a trend (p=0.08). Conclusion: Many patients with MSCC from HCC have a short survival, which can be predicted with a new tool. Radiation therapy can stop progression of motor dysfunction.
OriginalspracheEnglisch
ZeitschriftIn Vivo
Jahrgang29
Ausgabenummer6
Seiten (von - bis)749-752
Seitenumfang4
ISSN0258-851X
PublikationsstatusVeröffentlicht - 01.11.2015

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