TY - JOUR
T1 - Quantitative repeated open application testing with a rinse-off product in methyldibromo glutaronitrile-sensitive patients
T2 - Results of the IVDK
AU - Heratizadeh, Annice
AU - Killig, Claudia
AU - Worm, Margitta
AU - Soost, Stephanie
AU - Simon, Dagmar
AU - Bauer, Andrea
AU - Mahler, Vera
AU - Schuster, Christian
AU - Szliska, Christiane
AU - Frambach, Yvonne
AU - Eben, Ricarda
AU - Werfel, Thomas
AU - Uter, Wolfgang
AU - Schnuch, Axel
PY - 2010/1/1
Y1 - 2010/1/1
N2 - Background: While the use of methyldibromo glutaronitrile (MDBGN) in leave-on products is clearly associated with high sensitization or elicitation risk, such a clear-cut relation could be questioned with regard to rinse-off products. Objective: The objective of this study was to find a maximum non-eliciting concentration for rinse-off products in MDBGN patch test-positive patients. Patients and methods: We performed a use-related test [repeated open application test (ROAT)] in patients sensitized to MDBGN with a liquid soap containing three concentrations of MDBGN (50, 200, and 400 p.p.m. MDBGN, respectively). The soap at 50 p.p.m. was used twice daily for 4 weeks. If no reaction of the skin was observed, the product with the next higher concentration was used for another 4 weeks, etc. Results: In total, 32/37 evaluated cases [86.5%; lower exact one-sided 95% confidence limit (CL): 73.7%] did not react to any of the preparations. The remaining reacted as follows: 1/37 reacted to 50 p.p.m., 3/37 to 200 p.p.m., and 1/37 to 400 p.p.m. The cumulative non-response to 50 p.p.m. was 97.3% (lower CL: 87.8%). Conclusions: The majority of subjects sensitized to MDBGN-tolerated rinse-off products containing a maximum concentration of 400 p.p.m. A concentration in rinse-off products in the range of 50 p.p.m. could be regarded as safe for most individuals already sensitized. These concentrations will presumably prevent induction (sensitization) also.
AB - Background: While the use of methyldibromo glutaronitrile (MDBGN) in leave-on products is clearly associated with high sensitization or elicitation risk, such a clear-cut relation could be questioned with regard to rinse-off products. Objective: The objective of this study was to find a maximum non-eliciting concentration for rinse-off products in MDBGN patch test-positive patients. Patients and methods: We performed a use-related test [repeated open application test (ROAT)] in patients sensitized to MDBGN with a liquid soap containing three concentrations of MDBGN (50, 200, and 400 p.p.m. MDBGN, respectively). The soap at 50 p.p.m. was used twice daily for 4 weeks. If no reaction of the skin was observed, the product with the next higher concentration was used for another 4 weeks, etc. Results: In total, 32/37 evaluated cases [86.5%; lower exact one-sided 95% confidence limit (CL): 73.7%] did not react to any of the preparations. The remaining reacted as follows: 1/37 reacted to 50 p.p.m., 3/37 to 200 p.p.m., and 1/37 to 400 p.p.m. The cumulative non-response to 50 p.p.m. was 97.3% (lower CL: 87.8%). Conclusions: The majority of subjects sensitized to MDBGN-tolerated rinse-off products containing a maximum concentration of 400 p.p.m. A concentration in rinse-off products in the range of 50 p.p.m. could be regarded as safe for most individuals already sensitized. These concentrations will presumably prevent induction (sensitization) also.
UR - http://www.scopus.com/inward/record.url?scp=77952282922&partnerID=8YFLogxK
U2 - 10.1111/j.1600-0536.2010.01726.x
DO - 10.1111/j.1600-0536.2010.01726.x
M3 - Journal articles
C2 - 20557338
AN - SCOPUS:77952282922
SN - 0105-1873
VL - 62
SP - 330
EP - 337
JO - Contact Dermatitis
JF - Contact Dermatitis
IS - 6
ER -