Psoriasis and cardiometabolic traits: Modest association but distinct genetic architectures

Manja Koch; Hansjörg Baurecht; Janina S. Ried; Elke Rodriguez; Sabrina Schlesinger; Natalie Volks; Christian Gieger; Ina Maria Rückert; Luise Heinrich; Christina Willenborg; Catherine Smith; Annette Peters; Barbara Thorand; Wolfgang Koenig; Claudia Lamina; Henning Jansen; Florian Kronenberg; Jochen Seissler; Joachim Thiery; Wolfgang Rathmann; Heribert Schunkert; Jeanette Erdmann; Jonathan Barker; Rajan P. Nair; Lam C. Tsoi; James T. Elder; Ulrich Mrowietz; Michael Weichenthal; Sören Mucha; Stefan Schreiber; Andre Franke; Jochen Schmitt; Wolfgang Lieb; Stephan Weidinger

doi:10.1038/jid.2015.8

Psoriasis and cardiometabolic traits: Modest association but distinct genetic architectures

Manja Koch, Hansjörg Baurecht, Janina S. Ried, Elke Rodriguez, Sabrina Schlesinger, Natalie Volks, Christian Gieger, Ina Maria Rückert, Luise Heinrich, Christina Willenborg, Catherine Smith, Annette Peters, Barbara Thorand, Wolfgang Koenig, Claudia Lamina, Henning Jansen, Florian Kronenberg, Jochen Seissler, Joachim Thiery, Wolfgang RathmannHeribert Schunkert, Jeanette Erdmann, Jonathan Barker, Rajan P. Nair, Lam C. Tsoi, James T. Elder, Ulrich Mrowietz, Michael Weichenthal, Sören Mucha, Stefan Schreiber, Andre Franke, Jochen Schmitt, Wolfgang Lieb, Stephan Weidinger^*

^*Korrespondierende/r Autor/-in für diese Arbeit

57 Zitate (Scopus)

Abstract

Psoriasis has been linked to cardiometabolic diseases, but epidemiological findings are inconsistent. We investigated the association between psoriasis and cardiometabolic outcomes in a German cross-sectional study (n=4,185) and a prospective cohort of German Health Insurance beneficiaries (n=1,811,098). A potential genetic overlap was explored using genome-wide data from >22,000 coronary artery disease and >4,000 psoriasis cases, and with a dense genotyping study of cardiometabolic risk loci on 927 psoriasis cases and 3,717 controls. After controlling for major confounders, in the cross-sectional analysis psoriasis was significantly associated with type 2 diabetes (T2D, adjusted odds ratio (OR)=2.36; 95% confidence interval CI=1.26-4.41) and myocardial infarction (MI, OR=2.26; 95% CI=1.03-4.96). In the longitudinal study, psoriasis slightly increased the risk for incident T2D (adjusted relative risk (RR)=1.11; 95% CI=1.08-1.14) and MI (RR=1.14; 95% CI=1.06-1.22), with highest risk increments in systemically treated psoriasis, which accounted for 11 and 17 excess cases of T2D and MI per 10,000 person-years. Except for weak signals from within the major histocompatibility complex, there was no evidence of genetic risk loci shared between psoriasis and cardiometabolic traits. Our findings suggest that psoriasis, in particular severe psoriasis, increases the risk for T2D and MI, and that the genetic architecture of psoriasis and cardiometabolic traits is largely distinct.

Originalsprache	Englisch
Zeitschrift	Journal of Investigative Dermatology
Jahrgang	135
Ausgabenummer	5
Seiten (von - bis)	1283-1293
Seitenumfang	11
ISSN	0022-202X
DOIs	https://doi.org/10.1038/jid.2015.8
Publikationsstatus	Veröffentlicht - 22.05.2015

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We thank all individuals with psoriasis and CAD, their families, control individuals, and clinicians for their participation. The KORA study was initiated and financed by the Helmholtz Zentrum München—German Research Center for Environmental Health, which is funded by the German Federal Ministry of Education and Research and by the State of Bavaria. The project received infrastructure support through the DFG Clusters of Excellence “Inflammation at Interfaces” (grants EXC306 and EXC306/2), and was supported by the German Federal Ministry of Education and Research (BMBF) within the framework of the e:Med research and funding concept (e:AtheroSysMed and sysINFLAME, grant 01ZX1306A) and the PopGen 2.0 network (01EY1103). Support for the case-control psoriasis sample used for this study was provided by the National Institutes of Health (R01AR042742, R01AR050511, R01AR054966, R01AR062382, and R01AR065183 to JTE). JTE is supported by the Ann Arbor Veterans Affairs Hospital. This study makes use of data generated by the CARDIoGRAM Consortium and the Wellcome Trust Case-Control Consortium. Members of the consortia are listed in the Data Supplement. A full list of the Wellcome Trust Case-Control Consortium investigators who contributed to the generation of the data is available from www.wtccc.org.uk . Funding for the project was provided by the Wellcome Trust under award 076113 and 085475. We also acknowledge support from the Department of Health via the NIHR BioResource Clinical Research Facility and comprehensive Biomedical Research Centre award to Guy’s and St Thomas’ NHS Foundation Trust in partnership with King’s College London and King’s College Hospital NHS Foundation Trust. The funders had no role in the study design, in the collection, analysis, and interpretation of data, in the writing of the manuscript, and in the decision to submit the article for publication.

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Koch, M., Baurecht, H., Ried, J. S., Rodriguez, E., Schlesinger, S., Volks, N., Gieger, C., Rückert, I. M., Heinrich, L., Willenborg, C., Smith, C., Peters, A., Thorand, B., Koenig, W., Lamina, C., Jansen, H., Kronenberg, F., Seissler, J., Thiery, J., ... Weidinger, S. (2015). Psoriasis and cardiometabolic traits: Modest association but distinct genetic architectures. Journal of Investigative Dermatology, 135(5), 1283-1293. https://doi.org/10.1038/jid.2015.8

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title = "Psoriasis and cardiometabolic traits: Modest association but distinct genetic architectures",

abstract = "Psoriasis has been linked to cardiometabolic diseases, but epidemiological findings are inconsistent. We investigated the association between psoriasis and cardiometabolic outcomes in a German cross-sectional study (n=4,185) and a prospective cohort of German Health Insurance beneficiaries (n=1,811,098). A potential genetic overlap was explored using genome-wide data from >22,000 coronary artery disease and >4,000 psoriasis cases, and with a dense genotyping study of cardiometabolic risk loci on 927 psoriasis cases and 3,717 controls. After controlling for major confounders, in the cross-sectional analysis psoriasis was significantly associated with type 2 diabetes (T2D, adjusted odds ratio (OR)=2.36; 95\% confidence interval CI=1.26-4.41) and myocardial infarction (MI, OR=2.26; 95\% CI=1.03-4.96). In the longitudinal study, psoriasis slightly increased the risk for incident T2D (adjusted relative risk (RR)=1.11; 95\% CI=1.08-1.14) and MI (RR=1.14; 95\% CI=1.06-1.22), with highest risk increments in systemically treated psoriasis, which accounted for 11 and 17 excess cases of T2D and MI per 10,000 person-years. Except for weak signals from within the major histocompatibility complex, there was no evidence of genetic risk loci shared between psoriasis and cardiometabolic traits. Our findings suggest that psoriasis, in particular severe psoriasis, increases the risk for T2D and MI, and that the genetic architecture of psoriasis and cardiometabolic traits is largely distinct.",

author = "Manja Koch and Hansj{\"o}rg Baurecht and Ried, \{Janina S.\} and Elke Rodriguez and Sabrina Schlesinger and Natalie Volks and Christian Gieger and R{\"u}ckert, \{Ina Maria\} and Luise Heinrich and Christina Willenborg and Catherine Smith and Annette Peters and Barbara Thorand and Wolfgang Koenig and Claudia Lamina and Henning Jansen and Florian Kronenberg and Jochen Seissler and Joachim Thiery and Wolfgang Rathmann and Heribert Schunkert and Jeanette Erdmann and Jonathan Barker and Nair, \{Rajan P.\} and Tsoi, \{Lam C.\} and Elder, \{James T.\} and Ulrich Mrowietz and Michael Weichenthal and S{\"o}ren Mucha and Stefan Schreiber and Andre Franke and Jochen Schmitt and Wolfgang Lieb and Stephan Weidinger",

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Koch, M, Baurecht, H, Ried, JS, Rodriguez, E, Schlesinger, S, Volks, N, Gieger, C, Rückert, IM, Heinrich, L, Willenborg, C, Smith, C, Peters, A, Thorand, B, Koenig, W, Lamina, C, Jansen, H, Kronenberg, F, Seissler, J, Thiery, J, Rathmann, W, Schunkert, H, Erdmann, J, Barker, J, Nair, RP, Tsoi, LC, Elder, JT, Mrowietz, U, Weichenthal, M, Mucha, S, Schreiber, S, Franke, A, Schmitt, J, Lieb, W & Weidinger, S 2015, 'Psoriasis and cardiometabolic traits: Modest association but distinct genetic architectures', Journal of Investigative Dermatology, Jg. 135, Nr. 5, S. 1283-1293. https://doi.org/10.1038/jid.2015.8

TY - JOUR

T1 - Psoriasis and cardiometabolic traits: Modest association but distinct genetic architectures

AU - Koch, Manja

AU - Baurecht, Hansjörg

AU - Ried, Janina S.

AU - Rodriguez, Elke

AU - Schlesinger, Sabrina

AU - Volks, Natalie

AU - Gieger, Christian

AU - Rückert, Ina Maria

AU - Heinrich, Luise

AU - Willenborg, Christina

AU - Smith, Catherine

AU - Peters, Annette

AU - Thorand, Barbara

AU - Koenig, Wolfgang

AU - Lamina, Claudia

AU - Jansen, Henning

AU - Kronenberg, Florian

AU - Seissler, Jochen

AU - Thiery, Joachim

AU - Rathmann, Wolfgang

AU - Schunkert, Heribert

AU - Erdmann, Jeanette

AU - Barker, Jonathan

AU - Nair, Rajan P.

AU - Tsoi, Lam C.

AU - Elder, James T.

AU - Mrowietz, Ulrich

AU - Weichenthal, Michael

AU - Mucha, Sören

AU - Schreiber, Stefan

AU - Franke, Andre

AU - Schmitt, Jochen

AU - Lieb, Wolfgang

AU - Weidinger, Stephan

PY - 2015/5/22

Y1 - 2015/5/22

N2 - Psoriasis has been linked to cardiometabolic diseases, but epidemiological findings are inconsistent. We investigated the association between psoriasis and cardiometabolic outcomes in a German cross-sectional study (n=4,185) and a prospective cohort of German Health Insurance beneficiaries (n=1,811,098). A potential genetic overlap was explored using genome-wide data from >22,000 coronary artery disease and >4,000 psoriasis cases, and with a dense genotyping study of cardiometabolic risk loci on 927 psoriasis cases and 3,717 controls. After controlling for major confounders, in the cross-sectional analysis psoriasis was significantly associated with type 2 diabetes (T2D, adjusted odds ratio (OR)=2.36; 95% confidence interval CI=1.26-4.41) and myocardial infarction (MI, OR=2.26; 95% CI=1.03-4.96). In the longitudinal study, psoriasis slightly increased the risk for incident T2D (adjusted relative risk (RR)=1.11; 95% CI=1.08-1.14) and MI (RR=1.14; 95% CI=1.06-1.22), with highest risk increments in systemically treated psoriasis, which accounted for 11 and 17 excess cases of T2D and MI per 10,000 person-years. Except for weak signals from within the major histocompatibility complex, there was no evidence of genetic risk loci shared between psoriasis and cardiometabolic traits. Our findings suggest that psoriasis, in particular severe psoriasis, increases the risk for T2D and MI, and that the genetic architecture of psoriasis and cardiometabolic traits is largely distinct.

AB - Psoriasis has been linked to cardiometabolic diseases, but epidemiological findings are inconsistent. We investigated the association between psoriasis and cardiometabolic outcomes in a German cross-sectional study (n=4,185) and a prospective cohort of German Health Insurance beneficiaries (n=1,811,098). A potential genetic overlap was explored using genome-wide data from >22,000 coronary artery disease and >4,000 psoriasis cases, and with a dense genotyping study of cardiometabolic risk loci on 927 psoriasis cases and 3,717 controls. After controlling for major confounders, in the cross-sectional analysis psoriasis was significantly associated with type 2 diabetes (T2D, adjusted odds ratio (OR)=2.36; 95% confidence interval CI=1.26-4.41) and myocardial infarction (MI, OR=2.26; 95% CI=1.03-4.96). In the longitudinal study, psoriasis slightly increased the risk for incident T2D (adjusted relative risk (RR)=1.11; 95% CI=1.08-1.14) and MI (RR=1.14; 95% CI=1.06-1.22), with highest risk increments in systemically treated psoriasis, which accounted for 11 and 17 excess cases of T2D and MI per 10,000 person-years. Except for weak signals from within the major histocompatibility complex, there was no evidence of genetic risk loci shared between psoriasis and cardiometabolic traits. Our findings suggest that psoriasis, in particular severe psoriasis, increases the risk for T2D and MI, and that the genetic architecture of psoriasis and cardiometabolic traits is largely distinct.

UR - https://www.scopus.com/pages/publications/84928419406

U2 - 10.1038/jid.2015.8

DO - 10.1038/jid.2015.8

M3 - Journal articles

C2 - 25599394

AN - SCOPUS:84928419406

SN - 0022-202X

VL - 135

SP - 1283

EP - 1293

JO - Journal of Investigative Dermatology

JF - Journal of Investigative Dermatology

IS - 5

ER -

Psoriasis and cardiometabolic traits: Modest association but distinct genetic architectures

Abstract

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