Protein translocation into the endoplasmic reticulum (ER) two similar routes with different modes

Kai Uwe Kalies, Enno Hartmann*

*Korrespondierende/r Autor/-in für diese Arbeit
25 Zitate (Scopus)

Abstract

Protein translocation into the endoplasmic reticulum (ER) occurs cotranslationally with the ribosome tightly bound at the membrane, or post- translationally. Transport of polypeptides is performed by an elaborate structure in the ER membrane consisting of numerous proteins. Both pathways have been reconstituted in vitro using proteoliposomes that contain purified components. Primary structures of these key components have been identified and recent electron microscopic data provide a first impression of the tertiary structure of the translocation apparatus. However, the precise function of most subunits of the translocation apparatus is still a mystery and little is known about structural changes in the translocation site during a transport cycle.

OriginalspracheEnglisch
ZeitschriftEuropean Journal of Biochemistry
Jahrgang254
Ausgabenummer1
Seiten (von - bis)1-5
Seitenumfang5
ISSN0014-2956
PublikationsstatusVeröffentlicht - 15.05.1998

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