Protective features of peripheral monocytes/macrophages in stroke

Michael Gliem, Markus Schwaninger, Sebastian Jander*

*Korrespondierende/r Autor/-in für diese Arbeit
28 Zitate (Scopus)

Abstract

Hematogenous recruitment of monocytes and macrophages has traditionally been viewed as a harmful process causing exacerbation of brain injury after stroke. However, emerging findings suggest equally important protective features. Inflammatory monocytes are rapidly recruited to ischemic brain via a CCR2-dependent pathway and undergo secondary differentiation in the target tissue towards non-inflammatory macrophages, mediating neuroprotection and repair of the ischemic neurovascular unit. In contrast, independent recruitment of non-inflammatory monocytes via CX3CR1 does not occur. Thus, protective features of hematogenous macrophages mainly depend on initial CCR2-dependent cell recruitment. Under therapeutic considerations, specific modulation of monocyte-derived macrophages will therefore be more appropriate than non-selectively blocking their hematogenous recruitment. This article is part of a Special Issue entitled: Neuro Inflammation edited by Helga E. de Vries and Markus Schwaninger.

OriginalspracheEnglisch
ZeitschriftBiochimica et Biophysica Acta - Molecular Basis of Disease
Jahrgang1862
Ausgabenummer3
Seiten (von - bis)329-338
Seitenumfang10
ISSN0925-4439
DOIs
PublikationsstatusVeröffentlicht - 01.03.2016

Strategische Forschungsbereiche und Zentren

  • Forschungsschwerpunkt: Gehirn, Hormone, Verhalten - Center for Brain, Behavior and Metabolism (CBBM)

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