Prostaglandin E2 and atriopeptin III oppose the contractile effect of angiotensin II in rat kidney mesangial cell cultures

Joachim Fandrey; Wolfgang Jelkmann

doi:10.1016/0090-6980(88)90311-5

Prostaglandin E₂ and atriopeptin III oppose the contractile effect of angiotensin II in rat kidney mesangial cell cultures

Joachim Fandrey^*, Wolfgang Jelkmann

^*Korrespondierende/r Autor/-in für diese Arbeit

Institut für Physiologie

17 Zitate (Scopus)

Abstract

Effects of vasoconstrictory and of dilatory hormones were studied on the contractile activity of cultured rat kidney mesangial cells. By phase contrast microscopy, a rapid contraction was seen of most cells treated with angiotensine II (10⁻⁶ − 10⁻¹⁰ mol/L), which was sometimes followed by autonomous relaxation after 10 to 20 min. Prostaglandin E₂ and antriopeptin III prevented the contractile effect of angiotensin II in a dose-dependent manner. Angiotensin II, but not atriopeptine III, stimulated prostaglandin E₂ synthesis in mesangial cell cultures.

Originalsprache	Englisch
Zeitschrift	Prostaglandins
Jahrgang	36
Ausgabenummer	2
Seiten (von - bis)	249-257
Seitenumfang	9
ISSN	0090-6980
DOIs	https://doi.org/10.1016/0090-6980(88)90311-5
Publikationsstatus	Veröffentlicht - 1988

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SDG 3 – Gesundheit und Wohlergehen

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Forschungsschwerpunkt: Gehirn, Hormone, Verhalten - Center for Brain, Behavior and Metabolism (CBBM)

Dokumente

10.1016/0090-6980(88)90311-5

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abstract = "Effects of vasoconstrictory and of dilatory hormones were studied on the contractile activity of cultured rat kidney mesangial cells. By phase contrast microscopy, a rapid contraction was seen of most cells treated with angiotensine II (10−6 − 10−10 mol/L), which was sometimes followed by autonomous relaxation after 10 to 20 min. Prostaglandin E2 and antriopeptin III prevented the contractile effect of angiotensin II in a dose-dependent manner. Angiotensin II, but not atriopeptine III, stimulated prostaglandin E2 synthesis in mesangial cell cultures.",

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AU - Fandrey, Joachim

AU - Jelkmann, Wolfgang

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N2 - Effects of vasoconstrictory and of dilatory hormones were studied on the contractile activity of cultured rat kidney mesangial cells. By phase contrast microscopy, a rapid contraction was seen of most cells treated with angiotensine II (10−6 − 10−10 mol/L), which was sometimes followed by autonomous relaxation after 10 to 20 min. Prostaglandin E2 and antriopeptin III prevented the contractile effect of angiotensin II in a dose-dependent manner. Angiotensin II, but not atriopeptine III, stimulated prostaglandin E2 synthesis in mesangial cell cultures.

AB - Effects of vasoconstrictory and of dilatory hormones were studied on the contractile activity of cultured rat kidney mesangial cells. By phase contrast microscopy, a rapid contraction was seen of most cells treated with angiotensine II (10−6 − 10−10 mol/L), which was sometimes followed by autonomous relaxation after 10 to 20 min. Prostaglandin E2 and antriopeptin III prevented the contractile effect of angiotensin II in a dose-dependent manner. Angiotensin II, but not atriopeptine III, stimulated prostaglandin E2 synthesis in mesangial cell cultures.

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