Prostaglandin E2 and atriopeptin III oppose the contractile effect of angiotensin II in rat kidney mesangial cell cultures

Joachim Fandrey*, Wolfgang Jelkmann

*Korrespondierende/r Autor/-in für diese Arbeit
14 Zitate (Scopus)

Abstract

Effects of vasoconstrictory and of dilatory hormones were studied on the contractile activity of cultured rat kidney mesangial cells. By phase contrast microscopy, a rapid contraction was seen of most cells treated with angiotensine II (10−6 − 10−10 mol/L), which was sometimes followed by autonomous relaxation after 10 to 20 min. Prostaglandin E2 and antriopeptin III prevented the contractile effect of angiotensin II in a dose-dependent manner. Angiotensin II, but not atriopeptine III, stimulated prostaglandin E2 synthesis in mesangial cell cultures.

OriginalspracheEnglisch
ZeitschriftProstaglandins
Jahrgang36
Ausgabenummer2
Seiten (von - bis)249-257
Seitenumfang9
ISSN0090-6980
DOIs
PublikationsstatusVeröffentlicht - 1988

Strategische Forschungsbereiche und Zentren

  • Forschungsschwerpunkt: Gehirn, Hormone, Verhalten - Center for Brain, Behavior and Metabolism (CBBM)

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