Prospective longitudinal course of cognition in older subjects with mild parkinsonian signs

Stefanie Lerche; Kathrin Brockmann; Andrea Pilotto; Isabel Wurster; Ulrike Sünkel; Markus A Hobert; Anna-Katharina von Thaler; Claudia Schulte; Erik Stoops; Hugo Vanderstichele; Victor Herbst; Britta Brix; Gerhard W Eschweiler; Florian G Metzger; Walter Maetzler; Daniela Berg

doi:10.1186/s13195-016-0209-7

Prospective longitudinal course of cognition in older subjects with mild parkinsonian signs

Stefanie Lerche, Kathrin Brockmann, Andrea Pilotto, Isabel Wurster, Ulrike Sünkel, Markus A Hobert, Anna-Katharina von Thaler, Claudia Schulte, Erik Stoops, Hugo Vanderstichele, Victor Herbst, Britta Brix, Gerhard W Eschweiler, Florian G Metzger, Walter Maetzler, Daniela Berg

Klinik für Neurologie

17 Zitate (Scopus)

Abstract

BACKGROUND: Mild parkinsonian signs (MPS) are common in older people and are associated with an increased risk of different neurodegenerative diseases. This study prospectively evaluates the longitudinal course of cognitive performance in older individuals with MPS.

METHODS: From the TREND study, 480 individuals neurologically healthy at baseline, aged between 50 and 80 years, with complete follow-up data for three assessments within a mean of 43.8 months, were included in this analysis. Participants underwent a detailed cognitive test battery, evaluation of prodromal markers for neurodegenerative diseases and history of vascular diseases at each study visit. In addition, plasma levels of amyloid-beta (Aβ)1-40 and Aβ1-42 were evaluated longitudinally.

RESULTS: In 52 (11 %) of the 480 participants, MPS could be detected at baseline. These individuals had cognitive deficits significantly more often compared with controls at each time point and their cognitive performance showed a steeper decline during follow-up. In addition, their levels of plasma Aβ1-42 were significantly lower than those of controls, and declined more rapidly over time.

CONCLUSIONS: This longitudinal study shows that MPS are associated with cognitive decline and decrease in plasma Aβ1-42, possibly indicating an ongoing neurodegenerative process.

Originalsprache	Englisch
Zeitschrift	Alzheimer's Research and Therapy
Jahrgang	8
Ausgabenummer	1
Seiten (von - bis)	42
DOIs	https://doi.org/10.1186/s13195-016-0209-7
Publikationsstatus	Veröffentlicht - 10.10.2016

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10.1186/s13195-016-0209-7

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Lerche, S., Brockmann, K., Pilotto, A., Wurster, I., Sünkel, U., Hobert, M. A., von Thaler, A.-K., Schulte, C., Stoops, E., Vanderstichele, H., Herbst, V., Brix, B., Eschweiler, G. W., Metzger, F. G., Maetzler, W., & Berg, D. (2016). Prospective longitudinal course of cognition in older subjects with mild parkinsonian signs. Alzheimer's Research and Therapy, 8(1), 42. https://doi.org/10.1186/s13195-016-0209-7

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title = "Prospective longitudinal course of cognition in older subjects with mild parkinsonian signs",

abstract = "BACKGROUND: Mild parkinsonian signs (MPS) are common in older people and are associated with an increased risk of different neurodegenerative diseases. This study prospectively evaluates the longitudinal course of cognitive performance in older individuals with MPS.METHODS: From the TREND study, 480 individuals neurologically healthy at baseline, aged between 50 and 80 years, with complete follow-up data for three assessments within a mean of 43.8 months, were included in this analysis. Participants underwent a detailed cognitive test battery, evaluation of prodromal markers for neurodegenerative diseases and history of vascular diseases at each study visit. In addition, plasma levels of amyloid-beta (Aβ)1-40 and Aβ1-42 were evaluated longitudinally.RESULTS: In 52 (11 \%) of the 480 participants, MPS could be detected at baseline. These individuals had cognitive deficits significantly more often compared with controls at each time point and their cognitive performance showed a steeper decline during follow-up. In addition, their levels of plasma Aβ1-42 were significantly lower than those of controls, and declined more rapidly over time.CONCLUSIONS: This longitudinal study shows that MPS are associated with cognitive decline and decrease in plasma Aβ1-42, possibly indicating an ongoing neurodegenerative process.",

author = "Stefanie Lerche and Kathrin Brockmann and Andrea Pilotto and Isabel Wurster and Ulrike S{\"u}nkel and Hobert, \{Markus A\} and \{von Thaler\}, Anna-Katharina and Claudia Schulte and Erik Stoops and Hugo Vanderstichele and Victor Herbst and Britta Brix and Eschweiler, \{Gerhard W\} and Metzger, \{Florian G\} and Walter Maetzler and Daniela Berg",

year = "2016",

month = oct,

day = "10",

doi = "10.1186/s13195-016-0209-7",

language = "English",

volume = "8",

pages = "42",

journal = "Alzheimer's Research and Therapy",

issn = "1758-9193",

publisher = "BioMed Central Ltd",

number = "1",

}

Lerche, S, Brockmann, K, Pilotto, A, Wurster, I, Sünkel, U, Hobert, MA, von Thaler, A-K, Schulte, C, Stoops, E, Vanderstichele, H, Herbst, V, Brix, B, Eschweiler, GW, Metzger, FG, Maetzler, W & Berg, D 2016, 'Prospective longitudinal course of cognition in older subjects with mild parkinsonian signs', Alzheimer's Research and Therapy, Jg. 8, Nr. 1, S. 42. https://doi.org/10.1186/s13195-016-0209-7

TY - JOUR

T1 - Prospective longitudinal course of cognition in older subjects with mild parkinsonian signs

AU - Lerche, Stefanie

AU - Brockmann, Kathrin

AU - Pilotto, Andrea

AU - Wurster, Isabel

AU - Sünkel, Ulrike

AU - Hobert, Markus A

AU - von Thaler, Anna-Katharina

AU - Schulte, Claudia

AU - Stoops, Erik

AU - Vanderstichele, Hugo

AU - Herbst, Victor

AU - Brix, Britta

AU - Eschweiler, Gerhard W

AU - Metzger, Florian G

AU - Maetzler, Walter

AU - Berg, Daniela

PY - 2016/10/10

Y1 - 2016/10/10

N2 - BACKGROUND: Mild parkinsonian signs (MPS) are common in older people and are associated with an increased risk of different neurodegenerative diseases. This study prospectively evaluates the longitudinal course of cognitive performance in older individuals with MPS.METHODS: From the TREND study, 480 individuals neurologically healthy at baseline, aged between 50 and 80 years, with complete follow-up data for three assessments within a mean of 43.8 months, were included in this analysis. Participants underwent a detailed cognitive test battery, evaluation of prodromal markers for neurodegenerative diseases and history of vascular diseases at each study visit. In addition, plasma levels of amyloid-beta (Aβ)1-40 and Aβ1-42 were evaluated longitudinally.RESULTS: In 52 (11 %) of the 480 participants, MPS could be detected at baseline. These individuals had cognitive deficits significantly more often compared with controls at each time point and their cognitive performance showed a steeper decline during follow-up. In addition, their levels of plasma Aβ1-42 were significantly lower than those of controls, and declined more rapidly over time.CONCLUSIONS: This longitudinal study shows that MPS are associated with cognitive decline and decrease in plasma Aβ1-42, possibly indicating an ongoing neurodegenerative process.

AB - BACKGROUND: Mild parkinsonian signs (MPS) are common in older people and are associated with an increased risk of different neurodegenerative diseases. This study prospectively evaluates the longitudinal course of cognitive performance in older individuals with MPS.METHODS: From the TREND study, 480 individuals neurologically healthy at baseline, aged between 50 and 80 years, with complete follow-up data for three assessments within a mean of 43.8 months, were included in this analysis. Participants underwent a detailed cognitive test battery, evaluation of prodromal markers for neurodegenerative diseases and history of vascular diseases at each study visit. In addition, plasma levels of amyloid-beta (Aβ)1-40 and Aβ1-42 were evaluated longitudinally.RESULTS: In 52 (11 %) of the 480 participants, MPS could be detected at baseline. These individuals had cognitive deficits significantly more often compared with controls at each time point and their cognitive performance showed a steeper decline during follow-up. In addition, their levels of plasma Aβ1-42 were significantly lower than those of controls, and declined more rapidly over time.CONCLUSIONS: This longitudinal study shows that MPS are associated with cognitive decline and decrease in plasma Aβ1-42, possibly indicating an ongoing neurodegenerative process.

U2 - 10.1186/s13195-016-0209-7

DO - 10.1186/s13195-016-0209-7

M3 - Journal articles

C2 - 27724983

SN - 1758-9193

VL - 8

SP - 42

JO - Alzheimer's Research and Therapy

JF - Alzheimer's Research and Therapy

IS - 1

ER -

Prospective longitudinal course of cognition in older subjects with mild parkinsonian signs

Abstract

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