Prophylactic radiotherapy to intervention sites in malignant pleural mesothelioma - Single-institution experience and literature review

Stefan Janssen*, Bernd Schönhofer, Dirk Rades

*Korrespondierende/r Autor/-in für diese Arbeit
3 Zitate (Scopus)

Abstract

Aim: To evaluate the efficacy of prophylactic radiotherapy at intervention sites in patients with malignant pleural mesothelioma (MPM). Patients and Methods: From 05/2010 to 12/2014, 53 patients with histologically confirmed MPM were treated in order to prevent interventional site metastases. Irradiation was carried out with 3×7=21 Gy with 6-18 MeV electrons. Results: The mean follow-up period was 14.4 months (range=0-37 months). At the time of the analysis, 20 patients were alive. Three patients had developed a local recurrence within the irradiated site, representing a local recurrence rate of 5.7%. Toxicity was low, with transient grade I erythema found in 20.7% of patients. No grade II or higher toxicity was observed. Conclusion: Our simple and time-saving RT approach to interventional sites in patients with MPM was both effective and well-tolerated. This approach is easily integrated into general treatment concepts. Until publication of results from prospective randomized trials, prophylactic RT to intervention sites should remain standard.

OriginalspracheEnglisch
ZeitschriftAnticancer Research
Jahrgang35
Ausgabenummer7
Seiten (von - bis)4151-4154
Seitenumfang4
ISSN0250-7005
PublikationsstatusVeröffentlicht - 01.07.2015

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