TY - JOUR
T1 - Prominent psychiatric comorbidity in the dominantly inherited movement disorder myoclonus-dystonia
AU - Weissbach, Anne
AU - Kasten, Meike
AU - Grünewald, Anne
AU - Brüggemann, Norbert
AU - Trillenberg, Peter
AU - Klein, Christine
AU - Hagenah, Johann
PY - 2013/4/1
Y1 - 2013/4/1
N2 - Background: Neurological and psychiatric disorders show clinical overlap suggesting a shared pathophysiological background. We evaluated myoclonus-dystonia, a monogenic movement disorder as a disease model for inherited psychopathology. Method: We investigated 12 SGCE mutation carriers using standardized neurological and psychiatric examinations to assign DSM-IV diagnoses. Furthermore, we analyzed all studies in the Medline database which included psychiatric information on SGCE mutation-positive patients. Results: Of our twelve SGCE mutation carriers, 10 were older than 16 years. Two of them (20%) reported psychiatric diagnoses before our examination, which resulted in at least one psychiatric diagnosis in seven (70%) patients, most frequently anxiety (60%), depression (30%) or both. Substance abuse was observed in 20%, whereas obsessive-compulsive disorders were absent. One mutation carrier showed Axis 2 features. In the literature analysis, the ten studies using standardized tools covering DSM-IV criteria reported prevalences similar to those in our sample. This was three times the frequency of psychiatric disorders detected in 13 studies using clinical history or patient report only. Conclusion: About two thirds of SGCE mutation carriers develop psychiatric comorbidity and >80% are previously undiagnosed.
AB - Background: Neurological and psychiatric disorders show clinical overlap suggesting a shared pathophysiological background. We evaluated myoclonus-dystonia, a monogenic movement disorder as a disease model for inherited psychopathology. Method: We investigated 12 SGCE mutation carriers using standardized neurological and psychiatric examinations to assign DSM-IV diagnoses. Furthermore, we analyzed all studies in the Medline database which included psychiatric information on SGCE mutation-positive patients. Results: Of our twelve SGCE mutation carriers, 10 were older than 16 years. Two of them (20%) reported psychiatric diagnoses before our examination, which resulted in at least one psychiatric diagnosis in seven (70%) patients, most frequently anxiety (60%), depression (30%) or both. Substance abuse was observed in 20%, whereas obsessive-compulsive disorders were absent. One mutation carrier showed Axis 2 features. In the literature analysis, the ten studies using standardized tools covering DSM-IV criteria reported prevalences similar to those in our sample. This was three times the frequency of psychiatric disorders detected in 13 studies using clinical history or patient report only. Conclusion: About two thirds of SGCE mutation carriers develop psychiatric comorbidity and >80% are previously undiagnosed.
UR - http://www.scopus.com/inward/record.url?scp=84875237077&partnerID=8YFLogxK
U2 - 10.1016/j.parkreldis.2012.12.004
DO - 10.1016/j.parkreldis.2012.12.004
M3 - Journal articles
C2 - 23332219
AN - SCOPUS:84875237077
SN - 1353-8020
VL - 19
SP - 422
EP - 425
JO - Parkinsonism and Related Disorders
JF - Parkinsonism and Related Disorders
IS - 4
ER -
