Prognostic significance of YWHAZ expression in localized prostate cancer

K. Rüenauver, R. Menon, M. A. Svensson, J. Carlsson, W. Vogel, O. Andrén, M. Nowak, S. Perner*

*Korrespondierende/r Autor/-in für diese Arbeit
16 Zitate (Scopus)


Background:Prostate cancer (PCa) patients are often over-treated because of the lack of biomarkers needed to distinguish the lethal from the indolent form of PCa. YWHAZ was recently identified as a potential therapeutic target in castration-resistant PCa (CRPC). Therefore, this study focused on determining the prognostic significance of YWHAZ in localized PCa.Methods:YWHAZ expression was assessed by immunohistochemistry on formalin-fixed paraffin-embedded tissue from 213 men who underwent radical prostatectomy. Kaplan-Meier analysis and Cox proportional-hazards models were used to assess the prognostic value of YWHAZ intensity.Results:High YWHAZ expression was strongly associated with high Gleason score at the time of diagnosis (P<0.001) and PSA relapse (P=0.001). Importantly, patients with high expression of YWHAZ had a higher risk of CRPC development (P=0.002) and reduced survival time (P=0.002).Conclusions:Our findings indicate that YWHAZ could serve as a promising prognostic biomarker in localized PCa to predict poor prognosis and to identify a subgroup of tumors, which might benefit from earlier adjuvant or YWHAZ-targeted therapy.

ZeitschriftProstate Cancer and Prostatic Diseases
Seiten (von - bis)310-314
PublikationsstatusVeröffentlicht - 13.12.2014


Untersuchen Sie die Forschungsthemen von „Prognostic significance of YWHAZ expression in localized prostate cancer“. Zusammen bilden sie einen einzigartigen Fingerprint.