TY - JOUR
T1 - Prognostic factors for survival in patients treated with multimodal therapy for anaplastic thyroid cancer
AU - Käsmann, Lukas
AU - Bolm, Louisa
AU - Janssen, Stefan
AU - Rades, Dirk
PY - 2016/9
Y1 - 2016/9
N2 - Background/Aim: To identify predictors of survival after multimodal treatment including surgery plus postoperative radio(chemo)therapy) for anaplastic thyroid cancer. Patients and Methods: Nine potential factors were evaluated in nine patients regarding survival after 6, 12 and 24 months. These factors were age, gender, Karnofsky performance score, tumour stage, nodal stage, resection margin status, radiation dose, concurrent chemotherapy administered with irradiation and symptom control at the end of radiotherapy. Results: Survival rates were 67% at 6 months, 56% at 12 months and 22% at 24 months. On univariate survival analysis, concurrent radiochemotherapy (p=0.018) and controlled symptoms at the end of radiotherapy (p=0.03) were associated with improved survival. A trend for better survival was seen in patients with microscopically (R1) versus macroscopically (R2) residual disease (p=0.058). Conclusion: Prognostic factors for survival after multimodal treatment for anaplastic thyroid cancer were identified. Concurrent radio-chemotherapy resulted in significantly better survival and should be recommended.
AB - Background/Aim: To identify predictors of survival after multimodal treatment including surgery plus postoperative radio(chemo)therapy) for anaplastic thyroid cancer. Patients and Methods: Nine potential factors were evaluated in nine patients regarding survival after 6, 12 and 24 months. These factors were age, gender, Karnofsky performance score, tumour stage, nodal stage, resection margin status, radiation dose, concurrent chemotherapy administered with irradiation and symptom control at the end of radiotherapy. Results: Survival rates were 67% at 6 months, 56% at 12 months and 22% at 24 months. On univariate survival analysis, concurrent radiochemotherapy (p=0.018) and controlled symptoms at the end of radiotherapy (p=0.03) were associated with improved survival. A trend for better survival was seen in patients with microscopically (R1) versus macroscopically (R2) residual disease (p=0.058). Conclusion: Prognostic factors for survival after multimodal treatment for anaplastic thyroid cancer were identified. Concurrent radio-chemotherapy resulted in significantly better survival and should be recommended.
UR - http://www.scopus.com/inward/record.url?scp=84991577066&partnerID=8YFLogxK
U2 - 10.21873/anticanres.11023
DO - 10.21873/anticanres.11023
M3 - Journal articles
C2 - 27630315
AN - SCOPUS:84991577066
SN - 0250-7005
VL - 36
SP - 4697
EP - 4700
JO - Anticancer Research
JF - Anticancer Research
IS - 9
ER -