Predictors of freedom from atrial arrhythmia recurrence after cryoballoon ablation for persistent atrial fibrillation: A multicenter study

Bruno Reissmann*, Tobias Plenge, Christian Hendrik Heeger, Michael Schlüter, Peter Wohlmuth, Thomas Fink, Laura Rottner, Roland Richard Tilz, Shibu Mathew, Christine Lemeš, Tilman Maurer, Jakob Lüker, Arian Sultan, Barbara Bellmann, Britta Goldmann, Feifan Ouyang, Karl Heinz Kuck, Andreas Metzner, Daniel Steven, Andreas Rillig

*Korrespondierende/r Autor/-in für diese Arbeit
1 Zitat (Scopus)

Abstract

Aims: We sought to assess (1) clinical outcomes of second-generation cryoballoon (CB) ablation for persistent atrial fibrillation (AF), and (2) the association of baseline and procedural covariates with atrial arrhythmia recurrence (AAR) after ablation. Methods: A total of 135 patients (63 ± 11 years, 96 men [71%]) with persistent AF underwent CB ablation at three experienced electrophysiology centers. Freedom from AAR was estimated with the Kaplan-Meier method. A Cox proportional-hazards model was used to estimate the effects of baseline and procedural covariates on the likelihood of AAR. Results: Freedom from AAR at 6, 12, and 18 months was estimated at 91% (95% confidence interval [CI] 86%-96%), 75% (95% CI, 67%-83%), and 53% (95% CI, 43%-65%), respectively. The presence of an implantable cardiac device (Hazard ratio [HR] 3.09; 95% CI, 1.37-7.00; P =.007), a left atrial (LA) diameter > 50 mm (HR 1.69; 95% CI, 1.02-2.79; P =.043), and absence of antiarrhythmic drug (AAD) therapy before the ablation procedure (HR 3.12; 95% CI, 1.72-5.64; P <.001) were associated with AAR. A trend toward an increased risk of AAR was revealed for women (HR 1.73; 95% CI, 0.96-3.11; P =.069). Conclusions: CB ablation for persistent AF resulted in freedom from AAR about that reported for RF ablation. The presence of an implantable cardiac device, LA size, and absence of AAD therapy at baseline were associated with the risk of AAR.

OriginalspracheEnglisch
ZeitschriftJournal of Cardiovascular Electrophysiology
Jahrgang30
Ausgabenummer9
Seiten (von - bis)1436-1442
Seitenumfang7
ISSN1045-3873
DOIs
PublikationsstatusVeröffentlicht - 01.09.2019

Fingerprint

Untersuchen Sie die Forschungsthemen von „Predictors of freedom from atrial arrhythmia recurrence after cryoballoon ablation for persistent atrial fibrillation: A multicenter study“. Zusammen bilden sie einen einzigartigen Fingerprint.

Zitieren