PrEdictive value of coMbined pre-test proBability and blOod gas anaLysis In pulmonary emboliSM—the EMBOLISM study

Moritz Meusel*, Toni Pätz, Kim Gruber, Sebastian Kupp, Philipp Johannes Jensch, Roza Saraei, Alexander Fürschke, Friedhelm Sayk, Ingo Eitel, Sebastian Wolfrum

*Korrespondierende/r Autor/-in für diese Arbeit

Abstract

In patients with suspected pulmonary embolism (PE), the number of unnecessary computed tomography pulmonary angiography (CTPA) scans remains high, especially in patients with low pre-test probability (PTP). So far, no study showed any additional benefit of capillary blood gas analysis (BGA) in diagnostic algorithms for PE. In this retrospective analysis of patients with suspected PE and subsequent CTPA, clinical data, D-dimer levels and BGA parameters (including standardized PaO2) were analyzed. Logistic regression analyses were performed to identify independent predictors for PE and reduce unnecessary CTPA examinations in patients with low PTP according to Wells score. Of 1538 patients, PE was diagnosed in 433 patients (28.2%). The original Wells score (odds ratio: 1.381 [95% CI 1.300–1.467], p < 0.001) and standardized PaO2 (odds ratio: 0.987 [95% CI 0.978–0.996], p = 0.005) were independent predictors for PE. After cohort adjustment for low PTP a D-dimer cut-off < 1.5 mg/L (278 patients (18.1%) with 18 PE (6.5%)) was identified in which a standardized PaO2 > 65 mmHg reduced the number of unnecessary CTPA by 31.9% with a 100% sensitivity. This approach was further validated in additional 53 patients with low PTP. In this validation group CTPA examinations were reduced by 32.7%. No patient with PE was missed. With our novel algorithm combining BGA testing with low PTP according to Wells score, we were able to increase the D-Dimer threshold to 1.5 mg/L and reduce CTPA examinations by approximately 32%.

OriginalspracheEnglisch
ZeitschriftInternal and Emergency Medicine
Jahrgang17
Ausgabenummer8
Seiten (von - bis)2245-2252
Seitenumfang8
ISSN1828-0447
DOIs
PublikationsstatusVeröffentlicht - 11.2022

Strategische Forschungsbereiche und Zentren

  • Zentren: Universitäres Herzzentrum Lübeck (UHZL)

DFG-Fachsystematik

  • 205-12 Kardiologie, Angiologie

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