TY - JOUR
T1 - Predicting the risk of subsequent distant brain metastases after stereotactic radiosurgery or fractionated stereotactic radiotherapy in elderly patients
AU - Rades, Dirk
AU - Nguyen, Trang
AU - Dziggel, Liesa
AU - Blanck, Oliver
AU - Schild, Steven E.
N1 - Publisher Copyright:
© 2020 International Institute of Anticancer Research. All rights reserved.
Copyright:
Copyright 2020 Elsevier B.V., All rights reserved.
PY - 2020/7
Y1 - 2020/7
N2 - Background/Aim: Treatment for elderly patients with few brain metastases is controversial. A score was generated to predict distant brain metastases (DBMs) after stereotactic radiosurgery (SRS) or fractionated stereotactic radiotherapy (FSRT). Patients and Methods: Ten characteristics were retrospectively analyzed for freedom from new DBMs in 104 elderly patients receiving SRS or FSRT alone for 1-3 brain metastases. Characteristics that were significant or showed a trend on multivariate analysis were used for the score. Results: On multivariate analysis, favorable histology (p=0.026) and single brain metastasis (p=0.006) showed significant associations with freedom from DBMs. A trend was found for supra-tentorial location only (p=0.065). Three groups were designed, 10-14, 16-20 and 21-25 points, with 6-month rates of freedom from DBMs of 10%, 54% and 95%, respectively (p<0.0001). Positive predictive values to predict DBMs and freedom from DBMs at 6 months were 91% and 94%. Conclusion: This new score provided high accuracy in predicting DBMs and freedom from DBMs.
AB - Background/Aim: Treatment for elderly patients with few brain metastases is controversial. A score was generated to predict distant brain metastases (DBMs) after stereotactic radiosurgery (SRS) or fractionated stereotactic radiotherapy (FSRT). Patients and Methods: Ten characteristics were retrospectively analyzed for freedom from new DBMs in 104 elderly patients receiving SRS or FSRT alone for 1-3 brain metastases. Characteristics that were significant or showed a trend on multivariate analysis were used for the score. Results: On multivariate analysis, favorable histology (p=0.026) and single brain metastasis (p=0.006) showed significant associations with freedom from DBMs. A trend was found for supra-tentorial location only (p=0.065). Three groups were designed, 10-14, 16-20 and 21-25 points, with 6-month rates of freedom from DBMs of 10%, 54% and 95%, respectively (p<0.0001). Positive predictive values to predict DBMs and freedom from DBMs at 6 months were 91% and 94%. Conclusion: This new score provided high accuracy in predicting DBMs and freedom from DBMs.
UR - http://www.scopus.com/inward/record.url?scp=85087472402&partnerID=8YFLogxK
U2 - 10.21873/ANTICANRES.14406
DO - 10.21873/ANTICANRES.14406
M3 - Journal articles
C2 - 32620656
AN - SCOPUS:85087472402
SN - 0250-7005
VL - 40
SP - 4081
EP - 4086
JO - Anticancer Research
JF - Anticancer Research
IS - 7
ER -