TY - JOUR
T1 - Pre-and post-conditioning of the heart
T2 - An overview of cardioprotec-tive signaling pathways
AU - de Miranda, Denise Coutinho
AU - Faria, Gabriela de Oliveira
AU - Hermidorff, Milla Marques
AU - Silva, Fernanda Cacilda Dos Santos
AU - de Assis, Leonardo Vinícius Monteiro
AU - Isoldi, Mauro César
N1 - Funding Information:
We thank the funding agencies PROP-UFOP, FAPEMIG, CAPES, and CNPq for financial support. We also thank the Research Center of Biological Science (NU-PEB-UFOP). de Assis, L.V.M is a fellow of FAPESP (2018/16511-8).
Publisher Copyright:
© 2021 Bentham Science Publishers.
PY - 2021
Y1 - 2021
N2 - Since the discovery of ischemic pre-and post-conditioning, more than 30 years ago, the knowledge about the mechanisms and signaling pathways involved in these processes has significantly increased. In clinical practice, on the other hand, such advancement has yet to be seen. This article provides an overview of ischemic pre-, post-, remote, and pharmacological conditioning related to the heart. In addition, we reviewed the cardioprotective signaling pathways and therapeutic agents involved in the above-mentioned processes, aiming to provide a comprehensive evaluation of the advancements in the field. The advancements made over the last decades cannot be ignored and with the exponential growth in techniques and applications. The future of pre-and post-conditioning is promising.
AB - Since the discovery of ischemic pre-and post-conditioning, more than 30 years ago, the knowledge about the mechanisms and signaling pathways involved in these processes has significantly increased. In clinical practice, on the other hand, such advancement has yet to be seen. This article provides an overview of ischemic pre-, post-, remote, and pharmacological conditioning related to the heart. In addition, we reviewed the cardioprotective signaling pathways and therapeutic agents involved in the above-mentioned processes, aiming to provide a comprehensive evaluation of the advancements in the field. The advancements made over the last decades cannot be ignored and with the exponential growth in techniques and applications. The future of pre-and post-conditioning is promising.
UR - http://www.scopus.com/inward/record.url?scp=85116172933&partnerID=8YFLogxK
U2 - 10.2174/1570161119666201120160619
DO - 10.2174/1570161119666201120160619
M3 - Scientific review articles
C2 - 33222675
AN - SCOPUS:85116172933
SN - 1570-1611
VL - 19
SP - 499
EP - 524
JO - Current Vascular Pharmacology
JF - Current Vascular Pharmacology
IS - 5
ER -
