Pre- and perinatal complications in relation to Tourette syndrome and co-occurring obsessive-compulsive disorder and attention-deficit/hyperactivity disorder

Mohamed Abdulkadir; Jay A. Tischfield; Robert A. King; Thomas V. Fernandez; Lawrence W. Brown; Keun Ah Cheon; Barbara J. Coffey; Sebastian F.T.M. de Bruijn; Lonneke Elzerman; Blanca Garcia-Delgar; Donald L. Gilbert; Dorothy E. Grice; Julie Hagstrøm; Tammy Hedderly; Isobel Heyman; Hyun Ju Hong; Chaim Huyser; Laura Ibanez-Gomez; Young Key Kim; Young Shin Kim; Yun Joo Koh; Sodahm Kook; Samuel Kuperman; Andreas Lamerz; Bennett Leventhal; Andrea G. Ludolph; Marcos Madruga-Garrido; Athanasios Maras; Marieke D. Messchendorp; Pablo Mir; Astrid Morer; Alexander Münchau; Tara L. Murphy; Thaïra J.C. Openneer; Kerstin J. Plessen; Judith J.G. Rath; Veit Roessner; Odette Fründt; Eun Young Shin; Deborah A. Sival; Dong Ho Song; Jungeun Song; Anne Marie Stolte; Jennifer Tübing; Els van den Ban; Frank Visscher; Sina Wanderer; Martin Woods; Samuel H. Zinner; Matthew W. State; Gary A. Heiman; Pieter J. Hoekstra; Andrea Dietrich

doi:10.1016/j.jpsychires.2016.07.017

Pre- and perinatal complications in relation to Tourette syndrome and co-occurring obsessive-compulsive disorder and attention-deficit/hyperactivity disorder

Mohamed Abdulkadir^*, Jay A. Tischfield, Robert A. King, Thomas V. Fernandez, Lawrence W. Brown, Keun Ah Cheon, Barbara J. Coffey, Sebastian F.T.M. de Bruijn, Lonneke Elzerman, Blanca Garcia-Delgar, Donald L. Gilbert, Dorothy E. Grice, Julie Hagstrøm, Tammy Hedderly, Isobel Heyman, Hyun Ju Hong, Chaim Huyser, Laura Ibanez-Gomez, Young Key Kim, Young Shin KimYun Joo Koh, Sodahm Kook, Samuel Kuperman, Andreas Lamerz, Bennett Leventhal, Andrea G. Ludolph, Marcos Madruga-Garrido, Athanasios Maras, Marieke D. Messchendorp, Pablo Mir, Astrid Morer, Alexander Münchau, Tara L. Murphy, Thaïra J.C. Openneer, Kerstin J. Plessen, Judith J.G. Rath, Veit Roessner, Odette Fründt, Eun Young Shin, Deborah A. Sival, Dong Ho Song, Jungeun Song, Anne Marie Stolte, Jennifer Tübing, Els van den Ban, Frank Visscher, Sina Wanderer, Martin Woods, Samuel H. Zinner, Matthew W. State, Gary A. Heiman, Pieter J. Hoekstra, Andrea Dietrich

^*Korrespondierende/r Autor/-in für diese Arbeit

Klinik für Neurologie

32 Zitate (Scopus)

Abstract

Pre- and perinatal complications have been implicated in the onset and clinical expression of Tourette syndrome albeit with considerable inconsistencies across studies. Also, little is known about their role in co-occurring obsessive-compulsive disorder (OCD) and attention–deficit/hyperactivity disorder (ADHD) in individuals with a tic disorder. Therefore, we aimed to investigate the role of pre- and perinatal complications in relation to the presence and symptom severity of chronic tic disorder and co-occurring OCD and ADHD using data of 1113 participants from the Tourette International Collaborative Genetics study. This study included 586 participants with a chronic tic disorder and 527 unaffected family controls. We controlled for age and sex differences by creating propensity score matched subsamples for both case-control and within-case analyses. We found that premature birth (OR = 1.72) and morning sickness requiring medical attention (OR = 2.57) were associated with the presence of a chronic tic disorder. Also, the total number of pre- and perinatal complications was higher in those with a tic disorder (OR = 1.07). Furthermore, neonatal complications were related to the presence (OR = 1.46) and severity (b = 2.27) of co-occurring OCD and also to ADHD severity (b = 1.09). Delivery complications were only related to co-occurring OCD (OR = 1.49). We conclude that early exposure to adverse situations during pregnancy is related to the presence of chronic tic disorders. Exposure at a later stage, at birth or during the first weeks of life, appears to be associated with co-occurring OCD and ADHD.

Originalsprache	Englisch
Zeitschrift	Journal of Psychiatric Research
Jahrgang	82
Seiten (von - bis)	126-135
Seitenumfang	10
ISSN	0022-3956
DOIs	https://doi.org/10.1016/j.jpsychires.2016.07.017
Publikationsstatus	Veröffentlicht - 01.11.2016

Fördermittel

This study was supported by grants from the National Institute of Mental Health (R01MH092290 to LWB; R01MH092291 to SK; R01MH092292 to BJC; R01MH092293 to GAH and JAT; R01MH092513 to SHZ; R01MH092516 to DEG; R01MH092520 DLG; R01MH092289 to MWS; K08MH099424 to TVF) and NJCTS (NJ Center for Tourette Syndrome and Associated Disorders; to GAH and JAT). The content is solely the responsibility of the authors and does not necessarily represent the official views of the National Institutes of Health. This work was additionally supported by grants from Spain (to PM): the Instituto de Salud Carlos III (PI10/01674, PI13/01461), the Consejería de Economía, Innovación, Ciencia y Empresa de la Junta de Andalucía (CVI-02526, CTS-7685), the Consejería de Salud y Bienestar Social de la Junta de Andalucía (PI-0741/2010, PI-0437-2012, PI-0471-2013), the Sociedad Andaluza de Neurología, the Fundación Alicia Koplowitz, the Fundación Mutua Madrileña and the Jaques and Gloria Gossweiler Foundation; grants from Germany (to AM): Deutsche Forschungsgemeinschaft (DFG: MU 1692/3-1, MU 1692/4-1 and project C5 of the SFB 936). This research was also supported in part by an Informatics Starter Grant from the PhRMA Foundation (to YB). None of the study sponsors were involved in the study design; in the collection, analysis and interpretation of the data; in the writing of the report; and in the decision to submit the paper for publication. Dr. Gilbert has received honoraria from the Tourette Syndrome Association/Centers for Disease Control and Prevention and the American Academy of Pediatrics; has received book royalties from Elsevier, and one-time consulting fees for clinical trial design from Teva/Auspex pharmaceuticals, and has received compensation for expert testimony for the U.S. D.O.J. D.V.I.C. program. Dr. Gilbert has also received research support (for Tourette Syndrome, ADHD) from the NIH (NIMH R01 MH092520, NIMH R01 MH081854, NIMH R01 104651, NINDS R01 NS085023), and from Ecopipam Pharmaceuticals (clinical trial, Tourette Syndrome). Dr. Maras is a speaker, consultant for Lilly, Neurim, and Janssen. The following authors reported no biomedical financial interests or potential conflicts of interest: Mohamed Abdulkadir, Lawrence W. Brown, Keun-Ah Cheon, Barbara J. Coffey, Sebastian F.T.M. de Bruijn, Andrea Dietrich, Lonneke Elzerman, Thomas V. Fernandez, Blanca Garcia-Delgar, Dorothy E. Grice, Julie Hagstrøm, Tammy Hedderly, Gary A. Heiman, Isobel Heyman, Pieter J. Hoekstra, Hyun Ju Hong, Chaim Huyser, Laura Ibanez-Gomez, Young Key Kim, Young-Shin Kim, Robert King, Yun-Joo Koh, Sodahm Kook, Samuel Kuperman, Andreas Lamerz, Bennett L. Leventhal, Andrea G. Ludolph, Marcos Madruga-Garrido, Marieke D. Messchendorp, Pablo Mir, Astrid Morer, Alexander Münchau, Tara L. Murphy, Thaïra J.C. Openneer, Kerstin J. Plessen, Judith J.G. Rath, Veit Roessner, Odette Fründt, Eun-Young Shin, Deborah A. Sival, Dong-Ho Song, Jungeun Song, Matthew W. State, Anne-Marie Stolte, Jay A. Tischfield, Jennifer Tübing, Els van den Ban, Frank Visscher, Sina Wanderer, Martin Woods, and Samuel H. Zinner.

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10.1016/j.jpsychires.2016.07.017

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Abdulkadir, M., Tischfield, J. A., King, R. A., Fernandez, T. V., Brown, L. W., Cheon, K. A., Coffey, B. J., de Bruijn, S. F. T. M., Elzerman, L., Garcia-Delgar, B., Gilbert, D. L., Grice, D. E., Hagstrøm, J., Hedderly, T., Heyman, I., Hong, H. J., Huyser, C., Ibanez-Gomez, L., Kim, Y. K., ... Dietrich, A. (2016). Pre- and perinatal complications in relation to Tourette syndrome and co-occurring obsessive-compulsive disorder and attention-deficit/hyperactivity disorder. Journal of Psychiatric Research, 82, 126-135. https://doi.org/10.1016/j.jpsychires.2016.07.017

@article{d1b98811c8184b95b13d0b4a658fd85e,

title = "Pre- and perinatal complications in relation to Tourette syndrome and co-occurring obsessive-compulsive disorder and attention-deficit/hyperactivity disorder",

abstract = "Pre- and perinatal complications have been implicated in the onset and clinical expression of Tourette syndrome albeit with considerable inconsistencies across studies. Also, little is known about their role in co-occurring obsessive-compulsive disorder (OCD) and attention–deficit/hyperactivity disorder (ADHD) in individuals with a tic disorder. Therefore, we aimed to investigate the role of pre- and perinatal complications in relation to the presence and symptom severity of chronic tic disorder and co-occurring OCD and ADHD using data of 1113 participants from the Tourette International Collaborative Genetics study. This study included 586 participants with a chronic tic disorder and 527 unaffected family controls. We controlled for age and sex differences by creating propensity score matched subsamples for both case-control and within-case analyses. We found that premature birth (OR = 1.72) and morning sickness requiring medical attention (OR = 2.57) were associated with the presence of a chronic tic disorder. Also, the total number of pre- and perinatal complications was higher in those with a tic disorder (OR = 1.07). Furthermore, neonatal complications were related to the presence (OR = 1.46) and severity (b = 2.27) of co-occurring OCD and also to ADHD severity (b = 1.09). Delivery complications were only related to co-occurring OCD (OR = 1.49). We conclude that early exposure to adverse situations during pregnancy is related to the presence of chronic tic disorders. Exposure at a later stage, at birth or during the first weeks of life, appears to be associated with co-occurring OCD and ADHD.",

author = "Mohamed Abdulkadir and Tischfield, \{Jay A.\} and King, \{Robert A.\} and Fernandez, \{Thomas V.\} and Brown, \{Lawrence W.\} and Cheon, \{Keun Ah\} and Coffey, \{Barbara J.\} and \{de Bruijn\}, \{Sebastian F.T.M.\} and Lonneke Elzerman and Blanca Garcia-Delgar and Gilbert, \{Donald L.\} and Grice, \{Dorothy E.\} and Julie Hagstr{\o}m and Tammy Hedderly and Isobel Heyman and Hong, \{Hyun Ju\} and Chaim Huyser and Laura Ibanez-Gomez and Kim, \{Young Key\} and Kim, \{Young Shin\} and Koh, \{Yun Joo\} and Sodahm Kook and Samuel Kuperman and Andreas Lamerz and Bennett Leventhal and Ludolph, \{Andrea G.\} and Marcos Madruga-Garrido and Athanasios Maras and Messchendorp, \{Marieke D.\} and Pablo Mir and Astrid Morer and Alexander M{\"u}nchau and Murphy, \{Tara L.\} and Openneer, \{Tha{\"i}ra J.C.\} and Plessen, \{Kerstin J.\} and Rath, \{Judith J.G.\} and Veit Roessner and Odette Fr{\"u}ndt and Shin, \{Eun Young\} and Sival, \{Deborah A.\} and Song, \{Dong Ho\} and Jungeun Song and Stolte, \{Anne Marie\} and Jennifer T{\"u}bing and \{van den Ban\}, Els and Frank Visscher and Sina Wanderer and Martin Woods and Zinner, \{Samuel H.\} and State, \{Matthew W.\} and Heiman, \{Gary A.\} and Hoekstra, \{Pieter J.\} and Andrea Dietrich",

year = "2016",

month = nov,

day = "1",

doi = "10.1016/j.jpsychires.2016.07.017",

language = "English",

volume = "82",

pages = "126--135",

journal = "Journal of Psychiatric Research",

issn = "0022-3956",

publisher = "Elsevier Ltd",

}

Abdulkadir, M, Tischfield, JA, King, RA, Fernandez, TV, Brown, LW, Cheon, KA, Coffey, BJ, de Bruijn, SFTM, Elzerman, L, Garcia-Delgar, B, Gilbert, DL, Grice, DE, Hagstrøm, J, Hedderly, T, Heyman, I, Hong, HJ, Huyser, C, Ibanez-Gomez, L, Kim, YK, Kim, YS, Koh, YJ, Kook, S, Kuperman, S, Lamerz, A, Leventhal, B, Ludolph, AG, Madruga-Garrido, M, Maras, A, Messchendorp, MD, Mir, P, Morer, A, Münchau, A, Murphy, TL, Openneer, TJC, Plessen, KJ, Rath, JJG, Roessner, V, Fründt, O, Shin, EY, Sival, DA, Song, DH, Song, J, Stolte, AM, Tübing, J, van den Ban, E, Visscher, F, Wanderer, S, Woods, M, Zinner, SH, State, MW, Heiman, GA, Hoekstra, PJ & Dietrich, A 2016, 'Pre- and perinatal complications in relation to Tourette syndrome and co-occurring obsessive-compulsive disorder and attention-deficit/hyperactivity disorder', Journal of Psychiatric Research, Jg. 82, S. 126-135. https://doi.org/10.1016/j.jpsychires.2016.07.017

Pre- and perinatal complications in relation to Tourette syndrome and co-occurring obsessive-compulsive disorder and attention-deficit/hyperactivity disorder. / Abdulkadir, Mohamed; Tischfield, Jay A.; King, Robert A. et al.
in: Journal of Psychiatric Research, Jahrgang 82, 01.11.2016, S. 126-135.

Publikation: Beiträge in Fachzeitschriften › Zeitschriftenaufsätze › Forschung › Begutachtung

TY - JOUR

T1 - Pre- and perinatal complications in relation to Tourette syndrome and co-occurring obsessive-compulsive disorder and attention-deficit/hyperactivity disorder

AU - Abdulkadir, Mohamed

AU - Tischfield, Jay A.

AU - King, Robert A.

AU - Fernandez, Thomas V.

AU - Brown, Lawrence W.

AU - Cheon, Keun Ah

AU - Coffey, Barbara J.

AU - de Bruijn, Sebastian F.T.M.

AU - Elzerman, Lonneke

AU - Garcia-Delgar, Blanca

AU - Gilbert, Donald L.

AU - Grice, Dorothy E.

AU - Hagstrøm, Julie

AU - Hedderly, Tammy

AU - Heyman, Isobel

AU - Hong, Hyun Ju

AU - Huyser, Chaim

AU - Ibanez-Gomez, Laura

AU - Kim, Young Key

AU - Kim, Young Shin

AU - Koh, Yun Joo

AU - Kook, Sodahm

AU - Kuperman, Samuel

AU - Lamerz, Andreas

AU - Leventhal, Bennett

AU - Ludolph, Andrea G.

AU - Madruga-Garrido, Marcos

AU - Maras, Athanasios

AU - Messchendorp, Marieke D.

AU - Mir, Pablo

AU - Morer, Astrid

AU - Münchau, Alexander

AU - Murphy, Tara L.

AU - Openneer, Thaïra J.C.

AU - Plessen, Kerstin J.

AU - Rath, Judith J.G.

AU - Roessner, Veit

AU - Fründt, Odette

AU - Shin, Eun Young

AU - Sival, Deborah A.

AU - Song, Dong Ho

AU - Song, Jungeun

AU - Stolte, Anne Marie

AU - Tübing, Jennifer

AU - van den Ban, Els

AU - Visscher, Frank

AU - Wanderer, Sina

AU - Woods, Martin

AU - Zinner, Samuel H.

AU - State, Matthew W.

AU - Heiman, Gary A.

AU - Hoekstra, Pieter J.

AU - Dietrich, Andrea

PY - 2016/11/1

Y1 - 2016/11/1

N2 - Pre- and perinatal complications have been implicated in the onset and clinical expression of Tourette syndrome albeit with considerable inconsistencies across studies. Also, little is known about their role in co-occurring obsessive-compulsive disorder (OCD) and attention–deficit/hyperactivity disorder (ADHD) in individuals with a tic disorder. Therefore, we aimed to investigate the role of pre- and perinatal complications in relation to the presence and symptom severity of chronic tic disorder and co-occurring OCD and ADHD using data of 1113 participants from the Tourette International Collaborative Genetics study. This study included 586 participants with a chronic tic disorder and 527 unaffected family controls. We controlled for age and sex differences by creating propensity score matched subsamples for both case-control and within-case analyses. We found that premature birth (OR = 1.72) and morning sickness requiring medical attention (OR = 2.57) were associated with the presence of a chronic tic disorder. Also, the total number of pre- and perinatal complications was higher in those with a tic disorder (OR = 1.07). Furthermore, neonatal complications were related to the presence (OR = 1.46) and severity (b = 2.27) of co-occurring OCD and also to ADHD severity (b = 1.09). Delivery complications were only related to co-occurring OCD (OR = 1.49). We conclude that early exposure to adverse situations during pregnancy is related to the presence of chronic tic disorders. Exposure at a later stage, at birth or during the first weeks of life, appears to be associated with co-occurring OCD and ADHD.

AB - Pre- and perinatal complications have been implicated in the onset and clinical expression of Tourette syndrome albeit with considerable inconsistencies across studies. Also, little is known about their role in co-occurring obsessive-compulsive disorder (OCD) and attention–deficit/hyperactivity disorder (ADHD) in individuals with a tic disorder. Therefore, we aimed to investigate the role of pre- and perinatal complications in relation to the presence and symptom severity of chronic tic disorder and co-occurring OCD and ADHD using data of 1113 participants from the Tourette International Collaborative Genetics study. This study included 586 participants with a chronic tic disorder and 527 unaffected family controls. We controlled for age and sex differences by creating propensity score matched subsamples for both case-control and within-case analyses. We found that premature birth (OR = 1.72) and morning sickness requiring medical attention (OR = 2.57) were associated with the presence of a chronic tic disorder. Also, the total number of pre- and perinatal complications was higher in those with a tic disorder (OR = 1.07). Furthermore, neonatal complications were related to the presence (OR = 1.46) and severity (b = 2.27) of co-occurring OCD and also to ADHD severity (b = 1.09). Delivery complications were only related to co-occurring OCD (OR = 1.49). We conclude that early exposure to adverse situations during pregnancy is related to the presence of chronic tic disorders. Exposure at a later stage, at birth or during the first weeks of life, appears to be associated with co-occurring OCD and ADHD.

UR - https://www.scopus.com/pages/publications/84980332253

U2 - 10.1016/j.jpsychires.2016.07.017

DO - 10.1016/j.jpsychires.2016.07.017

M3 - Journal articles

C2 - 27494079

AN - SCOPUS:84980332253

SN - 0022-3956

VL - 82

SP - 126

EP - 135

JO - Journal of Psychiatric Research

JF - Journal of Psychiatric Research

ER -

Pre- and perinatal complications in relation to Tourette syndrome and co-occurring obsessive-compulsive disorder and attention-deficit/hyperactivity disorder

Abstract

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