Potential bidirectional communication between the liver and the central circadian clock in MASLD

Frédéric Gachon; Elisabetta Bugianesi; Gabriele Castelnuovo; Henrik Oster; Julie S. Pendergast; Sara Montagnese

doi:10.1038/s44324-025-00058-1

Potential bidirectional communication between the liver and the central circadian clock in MASLD

Frédéric Gachon^*, Elisabetta Bugianesi, Gabriele Castelnuovo, Henrik Oster, Julie S. Pendergast, Sara Montagnese^*

^*Korrespondierende/r Autor/-in für diese Arbeit

13 Zitate (Scopus)

Abstract

Most aspects of physiology and behaviour fluctuate every 24 h in mammals. These circadian rhythms are orchestrated by an autonomous central clock located in the suprachiasmatic nuclei that coordinates the timing of cellular clocks in tissues throughout the body. The critical role of this circadian system is emphasized by increasing evidence associating disruption of circadian rhythms with diverse pathologies. Accordingly, mounting evidence suggests a bidirectional relationship where disruption of rhythms by circadian misalignment may contribute to liver diseases while liver diseases alter the central clock and circadian rhythms in other tissues. Therefore, liver pathophysiology may broadly impact the circadian system and may provide a mechanistic framework for understanding and targeting metabolic diseases and adjust metabolic setpoints.

Originalsprache	Englisch
Aufsatznummer	15
Zeitschrift	NPJ Metabolic Health and Disease
Jahrgang	3
Ausgabenummer	1
ISSN	2948-2828
DOIs	https://doi.org/10.1038/s44324-025-00058-1
Publikationsstatus	Veröffentlicht - 12.2025

Fördermittel

This work was supported by grants from the National Health and Medical Research Council (Australia) Synergy Grant (2019260 to F.G.); National Institute of Health (NIH) (R01AG078241 to F.G., R01DK124774 to J.S.P.); the Novo Nordisk Foundation (Hallas-Møller Ascending Investigator grant #0087882 to F.G.); the National Science Foundation (NSF) (IOS-2045267 to J.S.P); the Relevant Researches of National Interest (PRIN) 2022 Next Generation EU (2022L273C9 to E.B. and 2022N2KJAM (CUP E53D23013280006) to S.M.); the Deutsche Forschungsgemeinschaft (DFG) Collaborative Research Centres (CRC 296 LocoTact-TP13 to H.O.); and the European Union Horizon 2020 H2020-SC1-BHC-2018-2020 (847949 to S.M.). The figures were created with BioRender.com.

Träger	Trägernummer
National Institutes of Health	R01DK124774, R01AG078241
Novo Nordisk Fonden	0087882
NextGenerationEU	2022N2KJAM, CUP E53D23013280006, 2022L273C9
Deutsche Forschungsgemeinschaft	CRC 296 LocoTact-TP13
National Health and Medical Research Council	2019260
Horizon 2020	847949
National Science Foundation	IOS-2045267

UN SDGs

Dieser Output leistet einen Beitrag zu folgendem(n) Ziel(en) für nachhaltige Entwicklung

SDG 3 – Gesundheit und Wohlergehen

Strategische Forschungsbereiche und Zentren

Forschungsschwerpunkt: Gehirn, Hormone, Verhalten - Center for Brain, Behavior and Metabolism (CBBM)

DFG-Fachsystematik

2.22-17 Endokrinologie, Diabetologie, Metabolismus
2.11-03 Zellbiologie
2.23-04 Kognitive, systemische und Verhaltensneurobiologie

Dokumente

10.1038/s44324-025-00058-1

Weitere Links

1 Abgeschlossen

SFB/TRR 296 LocoTact: Lokale Kontrolle der Schilddrüsenhormonwirkung
Führer-Sakel, D. (Sprecher*in), Mittag, J. (Stellv. Sprecher*in, Co-Sprecher*in), Kühnen, P. (Stellv. Sprecher*in, Co-Sprecher*in), Heuer, H. (Projektleiter*in (PI)), Schwaninger, M. (Projektleiter*in (PI)), Müller-Fielitz, H. (Projektleiter*in (PI)), Bechmann, I. (Projektleiter*in (PI)), Biebermann, H. (Projektleiter*in (PI)), Müller, T. (Projektleiter*in (PI)), Pfluger, P. (Projektleiter*in (PI)), Krude, H. (Projektleiter*in (PI)), Schülke-Gerstenfeld, M. (Projektleiter*in (PI)), Cirkel, A. (Projektleiter*in (PI)), Münte, T. (Projektleiter*in (PI)), Kleinschnitz, C. (Projektleiter*in (PI)), Langhauser, F. (Projektleiter*in (PI)), Engel, D. R. (Projektleiter*in (PI)), Möller, L. (Projektleiter*in (PI)), Kaiser, F. (Projektleiter*in (PI)), Oster, H. (Projektleiter*in (PI)), Kirchner, H. (Projektleiter*in (PI)), Spranger, J. (Projektleiter*in (PI)), Tacke, F. (Projektleiter*in (PI)), Wirth, E. K. (Projektleiter*in (PI)), Köhrle, J. (Projektleiter*in (PI)), Schomburg, L. (Projektleiter*in (PI)), Lange, C. M. (Projektleiter*in (PI)), Zwanziger, D. (Projektleiter*in (PI)), Mayerl, S. (Projektleiter*in (PI)), Stachelscheid, H. (Projektleiter*in (PI)), Opitz, R. (Projektleiter*in (PI)), Prasuhn, J. (Projektleiter*in (PI)), Lorenz, K. (Projektleiter*in (PI)), Köster, J. (Projektleiter*in (PI)), Mai, K. (Projektleiter*in (PI)), Püngel, T. (Projektleiter*in (PI)), Obermayer, B. (Projektleiter*in (PI)) & Rehwald, S. (Projektleiter*in (PI))
01.01.20 → 31.12.25
Projekt: DFG Verbundprojekte › DFG Sonderforschungsbereiche / Transregios (SFB/TR)

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title = "Potential bidirectional communication between the liver and the central circadian clock in MASLD",

abstract = "Most aspects of physiology and behaviour fluctuate every 24 h in mammals. These circadian rhythms are orchestrated by an autonomous central clock located in the suprachiasmatic nuclei that coordinates the timing of cellular clocks in tissues throughout the body. The critical role of this circadian system is emphasized by increasing evidence associating disruption of circadian rhythms with diverse pathologies. Accordingly, mounting evidence suggests a bidirectional relationship where disruption of rhythms by circadian misalignment may contribute to liver diseases while liver diseases alter the central clock and circadian rhythms in other tissues. Therefore, liver pathophysiology may broadly impact the circadian system and may provide a mechanistic framework for understanding and targeting metabolic diseases and adjust metabolic setpoints.",

author = "Fr{\'e}d{\'e}ric Gachon and Elisabetta Bugianesi and Gabriele Castelnuovo and Henrik Oster and Pendergast, \{Julie S.\} and Sara Montagnese",

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AU - Gachon, Frédéric

AU - Bugianesi, Elisabetta

AU - Castelnuovo, Gabriele

AU - Oster, Henrik

AU - Pendergast, Julie S.

AU - Montagnese, Sara

PY - 2025/12

Y1 - 2025/12

N2 - Most aspects of physiology and behaviour fluctuate every 24 h in mammals. These circadian rhythms are orchestrated by an autonomous central clock located in the suprachiasmatic nuclei that coordinates the timing of cellular clocks in tissues throughout the body. The critical role of this circadian system is emphasized by increasing evidence associating disruption of circadian rhythms with diverse pathologies. Accordingly, mounting evidence suggests a bidirectional relationship where disruption of rhythms by circadian misalignment may contribute to liver diseases while liver diseases alter the central clock and circadian rhythms in other tissues. Therefore, liver pathophysiology may broadly impact the circadian system and may provide a mechanistic framework for understanding and targeting metabolic diseases and adjust metabolic setpoints.

AB - Most aspects of physiology and behaviour fluctuate every 24 h in mammals. These circadian rhythms are orchestrated by an autonomous central clock located in the suprachiasmatic nuclei that coordinates the timing of cellular clocks in tissues throughout the body. The critical role of this circadian system is emphasized by increasing evidence associating disruption of circadian rhythms with diverse pathologies. Accordingly, mounting evidence suggests a bidirectional relationship where disruption of rhythms by circadian misalignment may contribute to liver diseases while liver diseases alter the central clock and circadian rhythms in other tissues. Therefore, liver pathophysiology may broadly impact the circadian system and may provide a mechanistic framework for understanding and targeting metabolic diseases and adjust metabolic setpoints.

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Potential bidirectional communication between the liver and the central circadian clock in MASLD

Abstract

Fördermittel

UN SDGs

Strategische Forschungsbereiche und Zentren

DFG-Fachsystematik

Dokumente

Weitere Links

Fingerprint

Projekte

SFB/TRR 296 LocoTact: Lokale Kontrolle der Schilddrüsenhormonwirkung

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